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Chemicals
Aminotadalafil CAS NO.385769-84-6
<p>Aminotadalafil is a potent structural analogue of the well-known PDE5 inhibitor Tadalafil, characterized by the introduction of an amino group which may influence its pharmacokinetic profile. This high-purity research chemical is primarily utilized in analytical laboratories for method development, quality control testing of pharmaceutical products, and as a reference standard for detecting undeclared adulterants…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Aminotadalafil |
| CAS NO. | 385769-84-6 |
| Appearance | White to off-white crystalline powder |
| Molecular Formula | C₂₁H₁₈N₄O₄ |
| Molecular Weight | 390.39 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in DMSO and methanol; slightly soluble in water; insoluble in ether and chloroform |
| Endotoxin | < 5 EU/mg (for pharmaceutical grade) |
| Biological Activity | Phosphodiesterase type 5 (PDE5) inhibitor; enhances nitric oxide-mediated vasodilation; promotes penile erection by increasing cGMP levels in corpus cavernosum smooth muscle cells |
| Storage Conditions | Store at 2–8°C, protected from light and moisture; avoid freeze-thaw cycles |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Aminotadalafil functions as a selective inhibitor of phosphodiesterase type 5 (PDE5), an enzyme responsible for the degradation of cyclic guanosine monophosphate (cGMP) in vascular smooth muscle cells. By competitively binding to the catalytic site of PDE5, it prevents the breakdown of cGMP, thereby amplifying the vasodilatory effects of nitric oxide. This mechanism leads to the relaxation of smooth muscle tissue and increased blood flow, which is the foundational principle for its research applications in vascular physiology and erectile function studies.
2.PRODUCT INDICATIONS
This product is indicated for use as a reference material in the forensic analysis of herbal supplements and sports nutrition products to identify illegal adulteration. It is also employed in pharmaceutical research for the synthesis and characterization of novel PDE5 inhibitors, as well as in clinical toxicology to develop detection assays. Researchers utilize it to study the structure-activity relationships of tadalafil derivatives and their potential effects on pulmonary arterial hypertension and benign prostatic hyperplasia models.
3.CLINICAL EFFICACY OF PRODUCT
While not approved for human therapeutic use, studies on its parent compound Tadalafil demonstrate high efficacy in improving erectile function scores and enabling successful intercourse in men with erectile dysfunction, with a unique long duration of action up to 36 hours. In research contexts, analogues like Aminotadalafil are evaluated for their potential to exhibit similar or enhanced binding affinity and selectivity, which is critical for understanding drug metabolism and the impact of structural modifications on biological activity.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags: Aminotadalafil #PDE5Inhibitor #ResearchChemical #TadalafilAnalogue #PharmaceuticalImpurity #AnalyticalStandard #ErectileDysfunctionResearch #Vasodilation
If you have any product requirements, please send an email to:sales@huanqiukeji9.com;whatsapp:85244219157
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Global Technology Co., Ltd.
