Baccatine III CAS NO.27548-93-2

TECHNICAL SPECIFICATIONS

1.MECHANISM OF ACTION

Unlike its derivative Paclitaxel, which directly stabilizes microtubules, Baccatine III exhibits a distinct immunomodulatory mechanism by selectively targeting the accumulation and suppressive function of Myeloid-Derived Suppressor Cells (MDSCs) within the tumor microenvironment. It inhibits the AKT/STAT6 and Smad2/3 signaling pathways, thereby blocking TGF-β1-induced immunosuppression and fibroblast differentiation, which effectively restores T-cell-mediated anti-tumor immunity without the severe cytotoxicity associated with microtubule stabilization.

2.PRODUCT INDICATIONS

This product is indicated for use as a key starting material in the industrial synthesis of Paclitaxel and Docetaxel, making it essential for pharmaceutical companies producing these life-saving cancer treatments. Additionally, it is utilized in preclinical research as a tool compound to study immunomodulation, specifically for investigating the role of MDSCs in cancer progression, fibrosis, and autoimmune diseases, catering to immunologists and oncologists exploring novel immunotherapy strategies.

3.CLINICAL EFFICACY OF PRODUCT

In vivo studies using murine models of breast and colon cancer have demonstrated that oral administration of Baccatine III at low doses (0.05-0.5 mg/kg) significantly inhibits tumor growth by reducing MDSC infiltration in the spleen and tumor site, leading to a marked decrease in tumor volume. While not directly administered as a standalone drug in human clinical practice, its efficacy is reflected in the successful production of Paclitaxel, which has established clinical efficacy in treating ovarian, breast, and lung cancers, with Baccatine III's role being foundational to ensuring the supply and cost-effectiveness of these therapies.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods 

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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