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Chemicals
aMarogentin CAS NO.21018-84-8
<p>Amarogentin, with the CAS number 21018-84-8, is a highly bioactive secoiridoid glycoside renowned for being one of the most intensely bitter natural substances known. It is a key bioactive constituent of several medicinal plants, most notably Swertia chirayita (Chiretta) and Gentiana lutea (Gentian). This compound serves as a primary marker for the quality and authenticity of these bitter herbs. Its complex struc…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Amarogentin |
| CAS NO. | 21018-84-8 |
| Appearance | White to yellowish crystalline or amorphous powder |
| Molecular Formula | C₂₉H₃₀O₁₃ |
| Molecular Weight | 586.54 g/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in DMSO, methanol, ethanol, pyridine; sparingly soluble in water; insoluble in non‑polar solvents (e.g., hexane) |
| Endotoxin | <0.1 EU/mg |
| Biological Activity | Exhibits anti‑inflammatory, hepatoprotective, anti‑leishmanial, and chemopreventive effects; modulates AMPK signaling and cell cycle/apoptosis pathways |
| Storage Conditions | Store in a cool, dry, dark place; sealed container at 2–8 °C (long‑term storage at −20 °C recommended); protect from moisture and light |
| Stock Location | Stock in USA |
| MOQ | 10g |
1.MECHANISM OF ACTION
- Amarogentin exhibits its diverse pharmacological effects through interaction with multiple molecular targets. Its potent antidiabetic activity is primarily mediated by stimulating insulin release from pancreatic β-cells via modulating KATP channels and increasing intracellular cAMP levels. It also enhances peripheral glucose utilization. Its hepatoprotective and antioxidant action involves scavenging free radicals, upregulating endogenous antioxidant enzymes (SOD, CAT, GSH), and modulating the Nrf2 pathway. Its anti-inflammatory and anti-cancer effects are linked to the inhibition of key signaling pathways, including NF-κB and STAT3, leading to reduced production of inflammatory cytokines and induction of apoptosis in cancer cells.
2.PRODUCT INDICATIONS
This product is intended as a critical research compound for exploring therapeutic and preventive applications. Primary research indications include metabolic disorders (for studies on diabetes mellitus, insulin resistance, and hyperglycemia), hepatology (for research on liver protection, anti-fibrotic effects, and chemical-induced hepatotoxicity), oncology (for chemopreventive and anti-proliferative research), and gastroenterology (for studying digestive stimulant and bitter tonic principles). It is also a key standard for authenticating and standardizing bitter herbal extracts used in traditional medicine.
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
3.CLINICAL EFFICACY OF PRODUCT
Note: Efficacy information is based on extensive preclinical research and traditional use, not a claim for approved human therapeutics.Preclinical studies on Amarogentin demonstrate highly promising bioactive efficacy. Research confirms its potent anti-hyperglycemic effects in diabetic animal models, comparable to some standard drugs. It shows significant hepatoprotection against toxins like paracetamol, carbon tetrachloride, and alcohol. Its anti-cancer potential is evident in studies showing inhibition of proliferation and induction of apoptosis in various human cancer cell lines. Traditional use supports its role as a digestive stimulant and febrifuge. These findings underscore its strong potential as a lead molecule for novel drug development, particularly for diabetes and liver disorders.
4.Certificate
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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Global Technology Co., Ltd.
