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Chemicals
Platycodin D CAS NO.58479-68-8
<p>Platycodin D, with the CAS registry number 58479-68-8, is the major and most potent triterpenoid saponin derived from the root of <em>Platycodon grandiflorus</em>(Balloon Flower), a traditional herb known as Jiegeng. It serves as the key quality marker for this medicinal plant. Known for its diverse and potent pharmacological activities, Platycodin D is a high-value compound in modern natural product research. Ou…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Platycodin D |
| CAS NO. | 58479-68-8 |
| Appearance | White to off-white amorphous powder or crystalline powder |
| Molecular Formula | C₅₇H₉₂O₂₉ |
| Molecular Weight | 1225.32 g/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in methanol, ethanol, DMSO; sparingly soluble in water; insoluble in non-polar solvents (e.g., hexane) |
| Endotoxin | <0.1 EU/mg |
| Biological Activity | Exhibits anti-inflammatory, immunomodulatory, anti-tumor, and expectorant activities; widely studied in traditional Chinese medicine pharmacology |
| Storage Conditions | Store in a cool, dry, dark place; sealed container at 2-8°C; avoid exposure to moisture and direct light to prevent degradation |
| Stock Location | Stock in USA |
| MOQ | 10g |
1.MECHANISM OF ACTION
- Platycodin D exerts its wide-ranging biological effects through complex and multi-target mechanisms. Its notable membrane-perturbing activity (surfactant property) can increase cell membrane permeability. A key anti-inflammatory pathway involves the potent inhibition of the NF-κB signaling cascade, leading to the downregulation of TNF-α, IL-6, and other pro-inflammatory cytokines. It induces apoptosis in cancer cells via both mitochondrial-dependent pathways (regulating Bcl-2/Bax, cytochrome c release) and death receptor pathways, and can also trigger autophagy. Furthermore, it activates the AMPK pathway to modulate glucose and lipid metabolism and stimulates mucociliary clearance in the respiratory tract.
2.PRODUCT INDICATIONS
This compound is supplied as a critical research material for investigating potential therapeutic applications. Primary research indications include respiratory health (for studies on cough, expectorant effects, and pulmonary inflammation), oncology (for its anti-proliferative and pro-apoptotic effects on various cancers), metabolic disorders (for research on obesity, hyperlipidemia, and insulin resistance), and inflammatory diseases (for conditions like arthritis and hepatitis). It is also a vital reference standard for the quality control and standardization of Platycodon grandiflorusextracts and related herbal formulations.
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
3.CLINICAL EFFICACY OF PRODUCT
Note: Efficacy information is derived from extensive preclinical research and traditional use, not an assertion of approved drug effects.Preclinical studies on Platycodin D demonstrate highly promising and potent bioactivity. Research confirms its effective expectorant and cough-suppressant properties. It shows significant anti-tumor activity against a wide range of cancer cell lines (e.g., lung, liver, colon) in vitro and in vivo. Studies indicate potent effects in reducing hepatic lipid accumulation, improving insulin sensitivity, and protecting against liver fibrosis. Its strong anti-inflammatory and immunomodulatory effects are well-documented in various disease models. These robust findings highlight its immense potential as a lead compound for new drug development.
4.Certificate
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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