Echinatin CAS NO.34221-41-5

TECHNICAL SPECIFICATIONS

1.MECHANISM OF ACTION

Echinatin exerts its biological effects by directly binding to Heat Shock Protein 90 (HSP90), inhibiting its ATPase activity and disrupting the interaction between HSP90 and the NLRP3 inflammasome, thereby suppressing the activation of inflammatory caspases. Additionally, it modulates the Nrf2/HO-1 signaling pathway to enhance cellular antioxidant defense systems and induces cell cycle arrest at the S or G2/M phase in cancer cells by inhibiting the Wnt/β-catenin pathway and activating p38 MAPK signaling, leading to apoptosis and inhibition of metastasis.

2.PRODUCT INDICATIONS

This product is indicated for use in preclinical research models targeting NLRP3 inflammasome-driven diseases such as septic shock, colitis, and non-alcoholic steatohepatitis (NASH), as well as in studies on various malignancies including osteosarcoma, bladder cancer, and non-small cell lung cancer (NSCLC). It is particularly relevant for researchers developing combination therapies to overcome chemoresistance and for those exploring natural compounds with dual inhibitory effects on EGFR and MET tyrosine kinases.

3.CLINICAL EFFICACY OF PRODUCT

In vivo studies demonstrate that Echinatin administration significantly ameliorates LPS-induced septic shock and dextran sodium sulfate-induced colitis in mice by reducing pro-inflammatory cytokine levels. It also shows efficacy in attenuating liver inflammation and fibrosis in NASH models and exhibits potent anti-tumor activity by inhibiting the growth and metastasis of human osteosarcoma and bladder cancer cells, often synergizing with conventional chemotherapeutic agents to enhance therapeutic outcomes.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods 

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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