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Chemicals
Phillyrin CAS NO.487-41-2
<p><strong>Phillyrin</strong> (CAS NO. 487-41-2) is a high-purity, single-component isolate derived from <em>Forsythia suspensa</em>. It is a <strong>lignan glycoside</strong> recognized as the key bioactive marker and quality determinant for this premier TCM herb. Celebrated for its <strong>broad-spectrum pharmacological profile</strong>, Phillyrin exhibits potent <strong>anti-viral (especially against influenza an…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Phillyrin |
| CAS NO. | 487-41-2 |
| Appearance | White to off-white crystalline powder or lyophilized solid |
| Molecular Formula | C₂₇H₃₄O₁₁ |
| Molecular Weight | 538.55 g/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in methanol, ethanol, DMSO; sparingly soluble in water; insoluble in non-polar solvents |
| Endotoxin | <0.1 EU/mg |
| Biological Activity | Exhibits anti-inflammatory, antioxidant, antiviral, and potential anti-obesity activities in preclinical studies |
| Storage Conditions | - Solid: 2–8°C, sealed, dry, protected from light and moisture- Solution: -80°C (long-term storage, ≤6 months); -20°C (short-term, ≤1 month) |
| Stock Location | Stock in USA |
| MOQ | 10g |
1.MECHANISM OF ACTION
- Dual Anti-viral Action:
- Direct Viral Inhibition: Acts against influenza A/B, RSV, and SARS-CoV-2 by interfering with viral entry (e.g., blocking hemagglutinin) and suppressing replication.
- Host-Directed Therapy: Mitigates virus-induced "cytokine storm" by modulating overactive immune responses, a key factor in severe COVID-19 and influenza.
- Potent Anti-inflammatory & Immunomodulation: Downregulates key pro-inflammatory pathways, including NF-κB, MAPK (p38, JNK, ERK), and the NLRP3 inflammasome, reducing the production of cytokines (TNF-α, IL-6, IL-1β) and mediators (NO, PGE2).
- Antioxidant Defense: Activates the cellular Nrf2/ARE pathway, boosting endogenous antioxidant enzymes (SOD, CAT, GSH-Px) to combat oxidative stress.
2.PRODUCT INDICATIONS
- Pharmaceutical & Virology Research: Lead compound for developing broad-spectrum anti-viral drugs, especially for influenza and coronavirus research.
- Immunology & Inflammation Research: Tool for studying NF-κB/NLRP3 pathway inhibitors and treatments for cytokine release syndrome (CRS), sepsis, and chronic inflammation.
- Traditional Chinese Medicine (TCM) Quality Control: The definitive chemical reference standard for authenticating and quantifying Forsythia suspensa(Lian Qiao) in raw herbs, extracts, and finished TCM products (e.g., Yin Qiao San).
- Nutraceutical Standardization: For standardizing immune-support and respiratory health supplements containing Forsythia extract.
Hepatoprotective Agent Research: Studying natural compounds for liver protection.
3.CLINICAL EFFICACY OF PRODUCT
- TCM Clinical Heritage: Forsythia suspensa(Lian Qiao), standardized by Phillyrin content, is a foundational herb in TCM used clinically for clearing heat, removing toxins, and treating upper respiratory infections (colds, flu, tonsillitis).
- Modern Clinical Formulations: Included in Chinese Pharmacopoeia-listed formulas (e.g., Lianhua Qingwen, Shuanghuanglian) used in hospitals for viral respiratory diseases. Its presence is a key quality and efficacy marker.
- Anti-COVID-19 Research Relevance: Extensively studied during the pandemic, with preclinical data showing anti-SARS-CoV-2 activity. It contributed to the research basis of several clinically used anti-COVID-19 TCM formulations.
Safety: Its use in TCM provides a strong precedent for safety, though purified compound studies continue.
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
4.Certificate
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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