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Chemicals
Trifolin CAS NO.23627-87-4
<p><strong>Trifolin</strong> (Kaempferol 3-O-β-D-galactopyranoside) (CAS NO. 23627-87-4) is a high-purity, naturally occurring <strong>flavonol O-glycoside</strong> isolated from a variety of plants, including legumes, tea, and other medicinal herbs. The galactosylation at the 3-position significantly enhances its <strong>water solubility</strong> compared to the aglycone kaempferol. Trifolin exhibits a broad spectr…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Trifolin |
| CAS NO. | 23627-87-4 |
| Appearance | White crystalline powder |
| Molecular Formula | C₂₁H₂₀O₁₁ |
| Molecular Weight | 464.37 g/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in methanol, ethanol, DMSO; sparingly soluble in water; insoluble in non-polar solvents |
| Endotoxin | <0.1 EU/mg |
| Biological Activity | Exhibits antioxidant, anti-inflammatory, and potential hepatoprotective activities in preclinical studies |
| Storage Conditions | - Solid: 2–8°C, sealed, dry, protected from light and moisture- Solution: -80°C (long-term storage, ≤6 months); -20°C (short-term, ≤1 month) |
| Stock Location | Stock in USA |
| MOQ | 10g |
1.MECHANISM OF ACTION
- Potent Antioxidant Activity: It acts as a direct free radical scavenger, neutralizing reactive oxygen and nitrogen species (ROS/RNS). It also upregulates the endogenous antioxidant defense system by activating the Nrf2/ARE signaling pathway, increasing the expression of enzymes like heme oxygenase-1 (HO-1) and superoxide dismutase (SOD).
- Anti-inflammatory Action: It inhibits the production of pro-inflammatory mediators (NO, PGE2, TNF-α, IL-6, IL-1β) by suppressing the activation of key inflammatory signaling pathways, primarily the NF-κB and MAPK (p38, JNK, ERK) pathways.
- Induction of Apoptosis & Cell Cycle Arrest: In cancer cells, it can induce programmed cell death (apoptosis) and cell cycle arrest. This is often mediated through the intrinsic mitochondrial pathway, involving modulation of Bcl-2 family proteins, cytochrome c release, and caspase activation. It may also inhibit survival pathways like PI3K/Akt.
2.PRODUCT INDICATIONS
- Antioxidant & Anti-inflammatory Research: For studying natural compounds in the context of oxidative stress-related and chronic inflammatory diseases (e.g., arthritis, metabolic syndrome, neuroinflammation).
- Oncology Research: As a cytotoxic and pro-apoptotic agent for investigating chemoprevention and therapy in various cancer models.
- Metabolic Disease Research: Investigating its potential as an α-glucosidase/α-amylase inhibitor for the management of type 2 diabetes.
- Hepatoprotective Research: Studies on liver injury, fibrosis, and non-alcoholic fatty liver disease (NAFLD).
- Neuropharmacology: Research in neurodegenerative diseases due to its antioxidant, anti-inflammatory, and potential AChE inhibitory activities.
3.CLINICAL EFFICACY OF PRODUCT
- Robust Preclinical Efficacy: In vitro and in vivo studies have demonstrated its significant antioxidant, anti-inflammatory, anti-diabetic, and anti-cancer activities in relevant animal models. The glycoside form is often a major circulating metabolite after consumption of kaempferol-rich foods.
- Bioavailability & Metabolite Relevance: As a glycoside, it represents a primary form in which kaempferol is ingested and potentially absorbed (after deglycosylation by gut enzymes or microbiota), making it highly relevant to human nutrition and pharmacology.
- Epidemiological & Clinical Context: High dietary intake of kaempferol and other flavonoids is associated with a reduced risk of cardiovascular diseases, certain cancers, and type 2 diabetes in population studies. Human intervention trials with kaempferol-rich extracts show benefits on vascular function and inflammation.
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
4.Certificate
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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