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Chemicals
Isosakuranetin CAS NO.480-43-3
<p><strong>Isosakuranetin</strong> (CAS NO. 480-43-3) is a high-purity, naturally occurring <strong>O-methylated flavanone</strong> found in various plants, particularly in the <em>Citrus</em>genus and other botanical sources. Chemically, it is the <strong>4'-O-methyl derivative of naringenin</strong>. This structural modification (methoxylation) enhances its <strong>lipophilicity, metabolic stability, and often…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Isosakuranetin |
| CAS NO. | 480-43-3 |
| Appearance | Off-white to yellow solid powder |
| Molecular Formula | C₁₆H₁₄O₅ |
| Molecular Weight | 226.23 g/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | DMSO: ≥25 mg/mL; DMF: ≥30 mg/mL; PBS (pH 7.2): ~0.5 mg/mL; Water: practically insoluble |
| Endotoxin | <0.1 EU/mg |
| Biological Activity | TRPM3 channel blocker; exhibits anti-inflammatory and antioxidant activities |
| Storage Conditions | - Solid: 2–8°C, sealed, protected from moisture and light- In solution: -80°C (long-term, 6 months); -20°C (short-term, 1 month) |
| Stock Location | Stock in USA |
| MOQ | 10g |
1.MECHANISM OF ACTION
- Potent Anti-inflammatory Action: It inhibits the production of pro-inflammatory mediators (e.g., NO, PGE2, TNF-α, IL-6, IL-1β) by suppressing the activation of key inflammatory signaling pathways, primarily the NF-κB and MAPK (p38, JNK, ERK) pathways.
- Antioxidant Activity: It acts as a direct free radical scavenger, neutralizing reactive oxygen and nitrogen species (ROS/RNS). It may also enhance the endogenous antioxidant defense system by activating the Nrf2/ARE signaling pathway.
- Enzyme Inhibition: It is a known inhibitor of several enzymes linked to disease:
- α-Glucosidase & α-Amylase: Inhibiting these carbohydrate-digesting enzymes reduces postprandial blood glucose spikes, indicating anti-diabetic potential.
- Acetylcholinesterase (AChE): Inhibition of AChE increases acetylcholine levels, which is relevant for Alzheimer's disease research.
- Tyrosinase: Inhibition of this enzyme suggests potential for skin-brightening applications.
2.PRODUCT INDICATIONS
- Inflammation & Immunology Research: For studying novel natural therapies for chronic inflammatory diseases (e.g., arthritis, colitis, atherosclerosis, neuroinflammation).
- Metabolic Disease Research: As an α-glucosidase/α-amylase inhibitor for type 2 diabetes and obesity studies.
- Oncology Research: Investigating its cytotoxic and pro-apoptotic mechanisms in various cancer models.
- Neuropharmacology: Research in neurodegenerative diseases (Alzheimer's, Parkinson's) due to its antioxidant, anti-inflammatory, and AChE inhibitory activities.
- Microbiology: Studying its effects against drug-resistant pathogens and biofilms.
Natural Product Chemistry & Analysis: As a high-purity reference standard for the identification, quantification, and quality control of flavanones in plant extracts, foods, and herbal products.
3.CLINICAL EFFICACY OF PRODUCT
- In Vitro & In Vivo Efficacy: Numerous studies demonstrate its significant anti-inflammatory, antioxidant, anti-diabetic (α-glucosidase inhibitory), and anti-cancer activities in cell-based and animal models. Its methoxylation often correlates with enhanced activity compared to naringenin.
- Traditional Medicine & Dietary Context: Its presence in edible plants (citrus) and medicinal herbs provides a basis for its safety and contributes to the documented health benefits of flavanone-rich diets.
- Research Significance: It serves as an excellent tool compound to study the structure-activity relationships (SAR) of flavonoids, particularly how methoxylation affects bioavailability and bioactivity. It is a promising lead for the development of nutraceuticals or drugs targeting inflammation, diabetes, and neurodegeneration.
Clinical Translation: While promising, its efficacy and safety in humans require validation through controlled clinical trials.
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
4.Certificate
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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