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Chemicals
Liraglutide CAS NO.204656-20-2
<p>Linaclotide (CAS NO.204656-20-2) is a 14-amino acid synthetic peptide therapeutic agent designed for the treatment of chronic gastrointestinal disorders. This first-in-class guanylate cyclase-C receptor agonist is engineered to activate intestinal fluid secretion and transit while reducing visceral pain sensitivity. Available as a high-purity white lyophilized powder with HPLC-verified quality, it represents a si…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Linaclotide |
| CAS NO. | 204656-20-2 |
| Appearance | a clear, colorless or almost colorless, sterile solution |
| Molecular Formula | C172H265N43O51 |
| Molecular Weight | 3751.38g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in water at a concentration of up to 10 mg/mL. It has limited solubility in common organic solvents such as methanol and dimethyl sulfoxide (DMSO). |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Linaclotide is a potent agonist of guanylate cyclase C (GC - C). It activates the GC - C receptor on the intestinal epithelial cells, leading to an increase in intracellular cyclic guanosine monophosphate (cGMP) levels. |
| Storage Conditions | Store at -20°C or below in a dry, dark environment. After reconstitution, store at 2-8°C and use promptly. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Linaclotide functions as a selective agonist of guanylate cyclase-C receptors located on the luminal surface of intestinal epithelial cells. Upon binding, it stimulates intracellular cyclic GMP production, leading to increased chloride and bicarbonate secretion into the intestinal lumen via the CFTR channel. This results in enhanced fluid secretion and accelerated intestinal transit. Additionally, elevated cGMP levels reduce nociceptor activity, thereby decreasing visceral hypersensitivity and pain perception.
2.PRODUCT INDICATIONS
Irritable Bowel Syndrome with Constipation: Primary treatment for adults with IBS-C, relieving abdominal pain and improving bowel function.
Chronic Idiopathic Constipation: Management of persistent constipation in adults unresponsive to conventional laxatives.
Research Applications: Investigation of gastrointestinal motility, visceral sensitivity, and guanylate cyclase-C signaling pathways.
Pharmaceutical Development: Active pharmaceutical ingredient for oral solid dosage formulations targeting lower GI disorders.
3.Clinical Efficacy of Product
Symptom Relief in IBS-C: Demonstrated significant reduction in abdominal pain and discomfort, with 33-50% of patients achieving clinically meaningful improvement in weekly responder endpoints.
Bowel Function Improvement: Increased complete spontaneous bowel movements, with treatment showing 3-4 additional CSBMs per week compared to placebo.
Rapid Onset: Therapeutic effects typically observed within the first week of treatment, with sustained efficacy throughout therapy duration.
Safety Profile: Generally well-tolerated with diarrhea as the most common adverse event, typically mild to moderate and transient in nature.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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If you have any product requirements, please send an email to:sales@huanqiukeji9.com;whatsapp:85244219157
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