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Chemicals
Urolithin M5 CAS NO.91485-02-8
<p><strong>Urolithin M5</strong> (CAS NO. 91485-02-8) is a high-purity, gut microbiota-derived metabolite belonging to the <strong>urolithin</strong> family (dibenzo-α-pyrones). It is a structural isomer of the more common Urolithin A, differing in the position of hydroxyl groups. Like other urolithins, it is formed via microbial transformation of ellagitannins. Urolithin M5 is a research compound of growing interes…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Urolithin C |
| CAS NO. | 165393-06-6 |
| Appearance | Off-white to beige powder |
| Molecular Formula | C₁₃H₈O₅ |
| Molecular Weight | 244.20 g/mol |
| Purity (RP-HPLC) | ≥97% |
| Solubility | Soluble in DMSO (2–125 mg/mL, sonication recommended); slightly soluble in methanol (with heating); insoluble in water |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Glucose-dependent activator of insulin secretion; L-type Ca²⁺ channel opener; induces apoptosis via mitochondrial pathway; exhibits antioxidant and antiproliferative activity |
| Storage Conditions | Powder: -20°C for 3 years / 4°C for 2 years (inert atmosphere recommended); In solution: -80°C for 6 months / -20°C for 1 month |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
- Estrogen Receptor Modulation (Potential Key Activity): Due to its specific hydroxylation pattern, Urolithin M5 is hypothesized to interact with estrogen receptors (ERα and ERβ). It may act as a phytoestrogen or selective estrogen receptor modulator (SERM), influencing estrogen-responsive tissues. This differentiates it from Urolithin A, which is not primarily known for estrogenic activity.
- Anti-inflammatory Action: Like other polyphenol metabolites, it likely exhibits anti-inflammatory properties, potentially by modulating pathways such as NF-κB and MAPK and inhibiting the production of pro-inflammatory cytokines (e.g., TNF-α, IL-6).
- Antioxidant Activity: It possesses inherent free radical scavenging ability due to its phenolic structure, contributing to cellular protection against oxidative stress.Cell Signaling & Metabolic Modulation: It may influence other cellular signaling cascades related to proliferation, apoptosis, and metabolism, though these require specific investigation.
2.PRODUCT INDICATIONS
- Comparative Urolithin & Structure-Activity Relationship (SAR) Research: Essential for mapping the distinct biological effects of different urolithin isomers to understand which structural features drive specific health benefits.
- Endocrinology & Women's/Men's Health Research: Investigating its potential as a natural SERM or phytoestrogen for conditions related to hormone balance, bone health, menopausal symptoms, or hormone-sensitive cancers (e.g., breast, prostate).
- Microbiome & Nutrigenomic Studies: As a specific metabolite to study inter-individual differences in ellagitannin metabolism and host-microbiome interactions.
- Inflammation Research: Exploring its anti-inflammatory potential in various cell and animal models.
Natural Product Chemistry: As a reference standard for the identification and quantification of urolithin isomers in complex biological samples (plasma, urine) and dietary supplements.
3.CLINICAL EFFICACY OF PRODUCT
- Research-Grade Compound: Its availability enables crucial comparative studies. It is detected in human biofluids after ellagitannin consumption, confirming it as a relevant human metabolite.
- Hypothesis-Driven Research: Its unique structure provides a tool to test specific hypotheses, particularly regarding estrogenic activity, that cannot be addressed with Urolithin A or B.
- Preclinical Data Gap: While Urolithins A and B have substantial preclinical data, systematic biological profiling of Urolithin M5 is still in early stages. Its clinical potential remains to be elucidated through targeted in vitro and in vivo studies.
- Foundation for Future Development: Understanding the full spectrum of bioactive urolithins (including M5) is essential for developing precision-nutrition approaches and next-generation postbiotic supplements that account for individual microbiome differences.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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