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Chemicals
Urolithin B CAS NO.1139-83-9
<p><strong>Urolithin B</strong> (CAS NO. 1139-83-9) is a high-purity, microbially derived <strong>urolithin</strong>, a class of benzo[c]chromen-6-one metabolites. It is produced in the gut via the transformation of dietary ellagitannins and is absorbed into systemic circulation. It is recognized for its diverse and potent <strong>biological activities</strong>, including <strong>anti-inflammatory, anti-cancer, anti…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Urolithin B |
| CAS NO. | 1139-83-9 |
| Appearance | White to beige powder / solid |
| Molecular Formula | C₁₃H₈O₃ |
| Molecular Weight | 212.20 g/mol |
| Purity (RP-HPLC) | ≥98.0% |
| Solubility | DMSO: 2–50 mg/mL (clear solution, may require warming); Water: Insoluble; Ethanol: ~12 mg/mL |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Inhibits NF-κB, JNK/ERK/Akt phosphorylation; activates AMPK; anti-inflammatory, antioxidant, and muscle hypertrophy-promoting effects |
| Storage Conditions | Store at -20°C (long-term) or 2–8°C (short-term), sealed, dry, and protected from light |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Induction of Mitophagy & Mitochondrial Biogenesis: It is a known inducer of mitophagy, the selective autophagic clearance of damaged mitochondria. This "rejuvenates" the cellular mitochondrial pool, improving energy metabolism and reducing age-related cellular dysfunction. It works by modulating pathways involving AMPK, SIRT1, and PGC-1α.
Potent Anti-inflammatory Action: It inhibits the production of pro-inflammatory cytokines (e.g., TNF-α, IL-6, IL-1β) and mediators (NO, PGE2) by suppressing the activation of the NF-κB and MAPK signaling pathways.
Induction of Apoptosis in Cancer Cells: It can inhibit cancer cell proliferation and induce apoptosis via mitochondrial pathways, cell cycle arrest, and inhibition of key oncogenic signals.
Modulation of Cellular Senescence: By improving mitochondrial function and reducing inflammation, it helps counteract the senescence-associated secretory phenotype (SASP), a key driver of aging.
2.PRODUCT INDICATIONS
- Aging & Longevity Research (Geroscience): Core compound for studying interventions that target fundamental aging processes, particularly mitophagy and cellular rejuvenation.
- Muscle Health & Sarcopenia: For research on age-related muscle loss, exercise performance, and muscle recovery, given the critical role of mitochondrial health in muscle function.
- Neurodegeneration Research: Studies on Alzheimer's, Parkinson's, and other neurodegenerative diseases where impaired mitophagy and neuroinflammation are key pathological features.
- Metabolic Health: Research in obesity, type 2 diabetes, and NAFLD, focusing on improving mitochondrial function in metabolic tissues.
- Cancer Chemoprevention: Investigating its role in preventing or slowing the progression of certain cancers.
3.CLINICAL EFFICACY OF PRODUCT
- Preclinical Efficacy: Strong evidence from cell and animal models shows benefits in improving mitochondrial function, extending healthspan, reducing inflammation, and protecting against muscle and neuronal decline.
- Clinical Evidence (for Urolithin Class):
- Human studies on Urolithin A (Mitopure®) have demonstrated that it is safe and effectively improves mitochondrial health and muscle function in older adults.
- It stimulates mitophagy and improves biomarkers of cellular health in human subjects.
- Significance of Urolithin B: While UA is the most studied, Urolithin B represents a distinct metabolite with its own pharmacokinetic and activity profile. Research on Urolithin B is crucial for understanding the full spectrum of bioactive compounds derived from ellagitannin-rich foods and for developing targeted interventions.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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