5-Demethylnobiletin CAS NO.2174-59-6

TECHNICAL SPECIFICATIONS

1.MECHANISM OF ACTION

5-Demethylnobiletin exerts its effects through multiple molecular pathways, primarily by acting as a direct inhibitor of 5-lipoxygenase (5-LOX) with an IC50 of 0.1 μM, which effectively blocks the production of pro-inflammatory leukotrienes without affecting COX-2 expression. It also modulates critical signaling cascades such as MAPK/ERK, PKC, and PKA, which are essential for promoting neuritogenesis and neuroprotection. Additionally, it influences lipid metabolism by activating the LKB1-AMPK pathway and enhancing LDL receptor activity, contributing to its anti-atherogenic and hypolipidemic effects.

2.PRODUCT INDICATIONS

This product is indicated for research and development in areas related to inflammation, neurological health, and metabolic syndrome. It is particularly suitable for studies focusing on neuroprotection, as it stimulates neurite outgrowth and the expression of neuronal markers like GAP43 and synaptophysin. Researchers investigating anti-obesity mechanisms will find it useful due to its ability to reduce triglyceride accumulation and body weight in high-fat diet models. It is also applicable for anti-cancer research, especially in targeting cell proliferation and apoptosis in various cancer cell lines.

3.CLINICAL EFFICACY OF PRODUCT

In preclinical models, 5-Demethylnobiletin has demonstrated significant efficacy in alleviating acute liver injury by reducing oxidative stress and inflammation, as evidenced by lowered serum aminotransferase levels and improved liver histology. It has shown potent anti-leukemic effects by inducing cell cycle arrest and apoptosis in acute myeloid leukemia cells. Furthermore, its neurotrophic actions have been validated in PC12 cells, where it promotes neurite formation, suggesting potential benefits for neurodegenerative conditions. These findings underscore its therapeutic promise across multiple disease models.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods 

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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