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Chemicals
Diosmetin-7-O-β-D-glucopyranoside CAS NO.20126-59-4
<p><strong>Diosmetin-7-O-β-D-glucopyranoside</strong> (CAS NO. 20126-59-4) is a high-purity, naturally occurring <strong>flavonoid glycoside</strong> (flavone O-glucoside). It is found in various medicinal and aromatic plants, such as olive leaves, citrus species, and other Lamiaceae members. It is the glucosylated form of the aglycone diosmetin. This glycoside exhibits significantly <strong>enhanced water solubilit…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Diosmetin-7-O-β-D-glucopyranoside |
| CAS NO. | 20126-59-4 |
| Appearance | Off-white to pale yellow crystalline powder |
| Molecular Formula | C₂₂H₂₂O₁₀ |
| Molecular Weight | 446.40 g/mol |
| Purity (RP-HPLC) | ≥98.0% |
| Solubility | Soluble in DMSO (~10 mg/mL), DMF, and methanol; sparingly soluble in water; slightly soluble in ethanol |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Exhibits antioxidant, anti-inflammatory, and hepatoprotective properties; may inhibit xanthine oxidase and reduce oxidative stress; potential for cardiovascular and metabolic health support |
| Storage Conditions | Store at -20°C, protected from light and moisture; avoid repeated freeze-thaw cycles |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
- Potent Antioxidant Activity: It acts as a direct free radical scavenger (ROS/RNS) and metal chelator. It also upregulates the endogenous antioxidant defense system via the Nrf2/ARE signaling pathway, increasing the expression of enzymes like heme oxygenase-1 (HO-1).
- Anti-inflammatory Action: It inhibits the production of pro-inflammatory mediators (NO, PGE2, TNF-α, IL-6) by suppressing the activation of key signaling pathways, including NF-κB and MAPKs (p38, JNK, ERK).
- Anti-microbial Activity: It demonstrates inhibitory effects against a range of bacteria and fungi, potentially by disrupting microbial cell membranes and biofilm formation.
- Venotonic & Vascular Protection (Potential): Similar to other flavonoid glycosides (e.g., diosmin), it may improve venous tone and microcirculation, reduce capillary fragility, and exhibit anti-edematous effects, though specific mechanisms for this compound require further elucidation.
2.PRODUCT INDICATIONS
- Nutraceutical & Functional Food Development: As a standardized active for dietary supplements targeting oxidative stress, chronic inflammation, and vascular health.
- Phlebotonic & Vascular Health Research: For studies on chronic venous insufficiency (CVI), varicose veins, and hemorrhoids, as a related analog to clinically used diosmin.
- Anti-inflammatory & Pain Research: Investigating natural compounds for inflammatory conditions like arthritis.
- Cosmetic Science: As an active in skincare products for its antioxidant, anti-redness, and potential anti-aging properties.
Phytochemistry & Analytical Standards: As a reference compound for the identification, quantification, and quality control of diosmetin derivatives in plant extracts (e.g., olive leaf extract) and herbal products.
3.CLINICAL EFFICACY OF PRODUCT
- Preclinical Evidence: Robust in vitro and in vivo studies demonstrate its potent antioxidant, anti-inflammatory, and anti-microbial activities.
- Clinical Evidence from Related Compounds: Its aglycone, diosmetin, and its isomer/derivative, diosmin (diosmetin-7-O-rutinoside, a disaccharide derivative), have well-established clinical use. Diosmin is a prescription and OTC phlebotonic drug in many countries, with proven efficacy in:
- Reducing symptoms of chronic venous insufficiency (CVI) and hemorrhoids.
- Post-surgical edema reduction.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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