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Chemicals
Tetramethylscutellarein CAS NO.1168-42-9
<p><strong>Tetramethylscutellarein (TMS)</strong> (CAS NO. 1168-42-9) is a synthetic, high-purity <strong>polymethoxylated flavone (PMF)</strong>. It is a methylated derivative of the natural flavonoid scutellarein, where all four hydroxyl groups are replaced by methoxy (-OCH3) groups. This structural modification significantly enhances its <strong>lipophilicity, metabolic stability, and membrane permeability</stron…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Tetramethylscutellarein |
| CAS NO. | 1168-42-9 |
| Appearance | White to light yellow powder or crystalline solid |
| Molecular Formula | C₁₉H₁₈O₆ |
| Molecular Weight | 342.34 g/mol |
| Purity (RP-HPLC) | ≥98.0% |
| Solubility | Soluble in chloroform, methanol, ethanol, and DMSO; slightly soluble in water; insoluble in petroleum ether |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Anti-inflammatory (inhibits NF-κB pathway, COX-2, iNOS), modulates bacterial drug resistance via efflux pump inhibition, accelerates blood coagulation, and shows anti-tumor activity against HepG2 cells (IC₅₀ = 20.08 μg/mL) |
| Storage Conditions | -20°C (long-term, months to years) or 0–4°C (short-term, days to weeks); protect from light and moisture; stock solutions at -80°C for up to 6 months, -20°C for up to 1 month |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
- Potent Anti-inflammatory Action: TMS is a powerful inhibitor of the NF-κB signaling pathway. It prevents the degradation of IκBα, thereby inhibiting NF-κB nuclear translocation and subsequent transcription of pro-inflammatory genes (e.g., iNOS, COX-2, TNF-α, IL-6). It also suppresses the activation of MAP kinases (p38, JNK, ERK).
- Induction of Apoptosis in Cancer Cells: It triggers mitochondrial-mediated apoptosis by upregulating pro-apoptotic proteins (Bax), downregulating anti-apoptotic proteins (Bcl-2, Bcl-xL), inducing cytochrome c release, and activating caspase-3 and -9. It can also induce cell cycle arrest.
- Neuroprotective Effects: It protects neuronal cells from oxidative stress and apoptosis induced by toxins (e.g., Aβ, glutamate, 6-OHDA) via its antioxidant activity and modulation of survival/apoptosis pathways (PI3K/Akt, MAPK).
- Anti-atherosclerotic Activity: It inhibits vascular smooth muscle cell (VSMC) proliferation and migration, key events in atherosclerosis, potentially through modulation of PDGF signaling.
2.PRODUCT INDICATIONS
- Inflammation & Immunology Research: As a potent and stable NF-κB/MAPK inhibitor for studying chronic inflammatory diseases, sepsis, arthritis, and neuroinflammation.
- Oncology Research: For investigating flavone-induced apoptosis, cell cycle arrest, and chemoprevention in various cancer models (e.g., breast, colon, liver, prostate).
- Neuropharmacology: Research in neurodegenerative diseases (Alzheimer's, Parkinson's), stroke, and neuropathic pain.
- Cardiovascular Research: Studying its effects on atherosclerosis, VSMC proliferation, and cardiovascular protection.
- Medicinal Chemistry: As a lead compound for the design and synthesis of novel polymethoxylated flavone derivatives with improved drug-like properties.
3.CLINICAL EFFICACY OF PRODUCT
- In Vitro Potency: Demonstrates significantly stronger anti-inflammatory and anti-proliferative activity than its non-methylated or partially methylated analogs in cell-based assays, validating the benefit of methoxylation.
- In Vivo Efficacy: Animal models of inflammation (e.g., carrageenan-induced paw edema, LPS-induced septic shock), cancer (xenograft models), and neurodegeneration show that TMS can effectively reduce inflammation, inhibit tumor growth, and protect neurons with good bioavailability and tolerability.
- Proof of Concept for PMFs: It is a prime example of how methoxylation enhances the biological activity and pharmacokinetic profile of flavonoids, providing a strategic blueprint for natural product-based drug development.
- Research Significance: Its well-defined mechanism and high activity make it an invaluable tool for dissecting flavone pharmacology. Clinical translation requires comprehensive ADMET and human trials.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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