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Chemicals
Coptisine CAS NO.3486-66-6
<p><strong>Coptisine</strong> (CAS NO. 3486-66-6) is a high-purity, naturally occurring <strong>isoquinoline alkaloid</strong> found predominantly in plants of the Ranunculaceae family, especially in <em>Coptis chinensis</em>(Huang Lian, Golden Thread) and related species. It is a yellow crystalline powder belonging to the protoberberine subclass. Coptisine is renowned for its wide spectrum of <strong>pharmacologica…
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Coptisine |
| CAS NO. | 3486-66-6 |
| Appearance | Yellow to orange-yellow crystalline powder |
| Molecular Formula | C₁₉H₁₄NO₄ |
| Molecular Weight | 323.32g/mol |
| Purity (RP-HPLC) | ≥98.0% |
| Solubility | - DMSO: ≥10 mg/mL - Methanol: Moderately soluble - Water: Slightly soluble (better in acidic aqueous solutions) |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Exhibits anti-inflammatory, antimicrobial, anti-tumor, and hepatoprotective activities; inhibits acetylcholinesterase and has potential for treating neurodegenerative diseases; isolated from Coptis chinensis and other medicinal herbs. |
| Storage Conditions | - Solid: -20°C (or 2–8°C for short-term), protect from light, sealed dry storage- In solution: -80°C for 6–12 months; -20°C for 1 month; avoid repeated freeze-thaw cycles |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Coptisine exerts its diverse biological effects through modulation of multiple cellular signaling pathways. Key mechanisms include:
- Anti-inflammatory Action: It potently inhibits the production of pro-inflammatory mediators (NO, PGE2, TNF-α, IL-6, IL-1β) by suppressing the activation of the NF-κB and MAPK (p38, JNK, ERK) signaling pathways.
- Induction of Apoptosis & Cell Cycle Arrest in Cancer Cells: It triggers mitochondrial-mediated apoptosis by modulating Bcl-2 family proteins, inducing ROS generation, and activating caspase cascades. It also arrests the cell cycle at the G0/G1 or G2/M phase by regulating cyclins and CDKs.
- Anti-microbial Activity: It disrupts bacterial cell membranes and inhibits biofilm formation, showing activity against a range of pathogens, including drug-resistant strains.
- Anti-diabetic Effects: It improves insulin sensitivity, inhibits α-glucosidase activity (reducing postprandial blood glucose), and protects pancreatic β-cells.
2.PRODUCT INDICATIONS
This product is indicated for advanced pharmacological and biomedical research:
- Inflammation & Immunology Research: For studying novel therapies for chronic inflammatory diseases, sepsis, and autoimmune conditions.
- Oncology Research: As a cytotoxic and pro-apoptotic agent for investigating anti-cancer mechanisms and chemoprevention in various cancer models (e.g., colon, liver, breast, lung).
- Microbiology & Anti-infective Research: Studying mechanisms against drug-resistant bacteria and fungi, and biofilm-related infections.
- Metabolic Disease Research: For type 2 diabetes, obesity, and non-alcoholic fatty liver disease (NAFLD) studies.
- Neuropharmacology: Research in neurodegenerative diseases (Alzheimer's, Parkinson's) and cognitive disorders.
- Natural Product & Phytochemistry: As a reference standard for authentication and standardization of Coptisextracts and related herbal medicines.
3.CLINICAL EFFICACY OF PRODUCT
Coptisine is a well-researched phytochemical, but it is not an approved single-entity drug. Its clinical efficacy is primarily demonstrated through the traditional use of Coptisextracts and supported by modern preclinical data:
- Traditional Medicine Validation: Coptis chinensis(rich in coptisine) has been used for millennia in Traditional Chinese Medicine (TCM) for treating "damp-heat" conditions, including gastroenteritis, dysentery, and inflammatory disorders, providing a long history of ethnopharmacological efficacy.
- Robust Preclinical Efficacy: Extensive in vitro and in vivo studies confirm its potent anti-inflammatory, anti-cancer, anti-diabetic, and anti-microbial activities in animal models of respective diseases.
- Pharmacological Marker: It is a major active component responsible for the therapeutic effects of Huang Lian. Its levels are used to standardize herbal preparations.
- Clinical Translation Potential: Its strong multi-target bioactivity profile makes it a prime candidate for drug development. However, its clinical efficacy as a purified compound in humans requires further pharmacokinetic and controlled clinical trials.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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