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Chemicals
6-Prenylnaringenin CAS NO.68236-13-5
<p><strong>6-Prenylnaringenin (6-PN)</strong> (CAS NO. 68236-13-5) is a high-purity, naturally occurring <strong>prenylated flavonoid</strong> primarily found in hops (<em>Humulus lupulus</em>) and some medicinal plants. It is a structural analog of naringenin modified with a prenyl (isopentenyl) group at the 6-position. This prenylation significantly enhances its lipophilicity, bioavailability, and biological activ…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | 6-Prenylnaringenin (also known as (2S)-6-Prenylnaringenin, 5,7,4'-Trihydroxy-6-prenylflavanone) |
| CAS NO. | 68236-13-5 |
| Appearance | White to off-white or light yellow powder/solid |
| Molecular Formula | C₂₀H₂₀O₅ |
| Molecular Weight | 340.37 g/mol |
| Purity (RP-HPLC) | ≥98.0% |
| Solubility | - DMSO: ≥10 mg/mL (up to 180 mg/mL with sonication) - Methanol/ethanol: Moderately soluble - Poorly soluble in water (≈1.53×10⁻² g/L) |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Acts as a GABAₐ positive allosteric modulator; exhibits anticancer, antimicrobial, neuroprotective, and weak estrogenic activities; inhibits T-type calcium channels and induces apoptosis in cancer cells. |
| Storage Conditions | - Solid: -20°C (or 2–8°C for short-term), protect from light, sealed dry storage- In solution: -80°C for 6–12 months; -20°C for 1 month; avoid repeated freeze-thaw cycles |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
6-Prenylnaringenin exerts its effects through multiple pathways, with estrogenic activity being the most prominent:
- Potent Estrogenic Agonist: 6-PN binds with high affinity to both estrogen receptor alpha (ERα) and beta (ERβ), acting as a strong agonist. It preferentially activates ERα, which mediates its effects on bone formation, breast tissue, and the cardiovascular system. This makes it a key compound for studying ER-mediated physiology and pathology.
- Induction of Apoptosis in Cancer Cells: In hormone-sensitive cancers (e.g., breast, prostate), it can exert anti-proliferative and pro-apoptotic effects. The mechanisms may involve ER-dependent signaling, cell cycle arrest, modulation of Bcl-2 family proteins, and inhibition of key survival pathways.
- Anti-inflammatory Action: It inhibits the production of pro-inflammatory mediators (e.g., NO, PGE2, cytokines) by suppressing the NF-κB and MAPK signaling pathways.
- Osteogenic Activity: By activating ERs, it stimulates the differentiation and activity of osteoblasts (bone-forming cells), promoting bone formation and density, which is relevant for osteoporosis research.
2.PRODUCT INDICATIONS
This product is indicated for advanced preclinical and mechanistic research in:
- Endocrinology & Menopause Research: As a model phytoestrogen for studying estrogen replacement therapy, menopausal symptoms, and hormone-dependent processes.
- Oncology Research: Investigating its dual role in hormone-dependent cancers (both potential protective and therapeutic effects) and as a chemopreventive agent.
- Osteoporosis & Bone Biology: Researching natural compounds that promote bone formation and combat bone loss.
- Inflammation & Immunology: Studying natural anti-inflammatory agents for chronic inflammatory diseases.
- Natural Product & Nutraceutical Science: As a marker compound for hops quality, and for developing standardized extracts or supplements targeting women's health, bone health, and inflammation.
3.CLINICAL EFFICACY OF PRODUCT
6-Prenylnaringenin is a research phytochemical, and its clinical efficacy in humans is still under investigation. Its potential is strongly supported by extensive preclinical data and emerging human studies:
- Preclinical Efficacy: Demonstrates potent in vitro and in vivo estrogenic activity, effective bone anabolic effects in ovariectomized (post-menopausal) animal models, and anti-proliferative activity in cancer models.
- Human Clinical Data (Emerging): Preliminary human intervention studies with hops extracts rich in 6-PN have shown:
- Reduction in menopausal symptoms (hot flashes, night sweats) in perimenopausal women.
- Positive effects on markers of bone turnover (increasing bone formation markers).
- Improvement in sleep and mood parameters.
- Research Significance: Its status as the most potent known dietary phytoestrogen makes it a critical compound for understanding the health effects of hops, beer, and phytoestrogen supplements. More large-scale, long-term human trials are needed to fully establish its safety and efficacy profile for specific health conditions.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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