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Chemicals
Ginsenoside Rk1 CAS NO.494753-69-4
<p><strong>Ginsenoside Rk1</strong> (CAS NO. 494753-69-4) is a high-purity, rare <strong>ginsenoside</strong> belonging to the panaxadiol group. It is a <strong>steam-processed or heat-treated derivative</strong> of major ginsenosides (e.g., Rg3, Rg5, Rh1) found in Panax ginseng (Korean ginseng) and other Panax species. This transformation occurs during traditional red ginseng preparation or modern processing, signi…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Ginsenoside Rk1 |
| CAS NO. | 494753-69-4 |
| Appearance | White to light yellow solid/powder |
| Molecular Formula | C42H70O12 |
| Molecular Weight | 767 g/mol |
| Purity (RP-HPLC) | ≥98.0% |
| Solubility | DMSO: 50–100 mg/mL (with sonication) - Ethanol: 100 mg/mL (with sonication) - Poorly soluble in water |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Anti-inflammatory, anti-tumor, antiplatelet aggregation, nephroprotective, and antimicrobial activities; induces apoptosis via ROS generation and PI3K/Akt pathway inhibition |
| Storage Conditions | - Solid: -20°C, protect from light, sealed dry storage- In solution: -80°C for 6 months; -20°C for 1 month (protect from light) |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Ginsenoside Rk1 exerts its diverse effects through modulation of multiple signaling pathways. Key mechanisms include:
- Induction of Apoptosis in Cancer Cells: It activates both the intrinsic (mitochondrial) and extrinsic (death receptor) apoptotic pathways. It upregulates pro-apoptotic proteins (e.g., Bax, Bad), downregulates anti-apoptotic proteins (e.g., Bcl-2, Bcl-xL), induces cytochrome c release, and activates caspases (caspase-3, -9), leading to programmed cancer cell death. It can also induce cell cycle arrest.
- Anti-inflammatory Action: It inhibits the production of inflammatory mediators (NO, PGE2, TNF-α, IL-6) by suppressing the activation of the NF-κB and MAPK signaling pathways.
- Neuroprotection: It protects neuronal cells from oxidative stress and apoptosis induced by various toxins (e.g., Aβ, glutamate). It may modulate neurotransmitter systems and promote neuronal survival, relevant to Alzheimer's and Parkinson's disease research.
Anti-platelet Aggregation: It inhibits platelet activation and aggregation, which may contribute to cardiovascular protection.
2.PRODUCT INDICATIONS
This product is indicated for advanced preclinical and pharmacological research:
- Oncology & Cancer Research: As a potent anti-cancer agent for studying apoptosis, autophagy, metastasis, and chemosensitization in various cancer models (e.g., liver, lung, colon, breast, melanoma).
- Neuropharmacology & Neuroscience: For research on neurodegenerative diseases, cognitive function, and neuroprotection.
- Inflammation & Immunology: Investigating its effects on chronic inflammatory diseases, sepsis, and immune modulation.
- Cardiovascular Research: Studying its anti-thrombotic and cardioprotective potential.
- Natural Product & Formulation Science: As a marker compound for the quality control of processed ginseng products (red ginseng) and for developing enhanced bioavailability nutraceuticals.
3.CLINICAL EFFICACY OF PRODUCT
Ginsenoside Rk1 is a research compound, and its clinical efficacy in humans is not yet established through large-scale, controlled trials. Its therapeutic potential is strongly supported by robust preclinical evidence:
- In Vitro Anti-cancer Efficacy: Demonstrates significant cytotoxic and pro-apoptotic activity against a wide spectrum of human cancer cell lines, often with higher potency than its major ginsenoside precursors.
- In Vivo Anti-tumor Efficacy: Animal xenograft studies show that Ginsenoside Rk1 can effectively inhibit tumor growth and metastasis with good tolerability, highlighting its potential as a chemotherapeutic or chemopreventive agent.
- In Vivo Neuroprotective Efficacy: Animal models of neurodegenerative diseases and brain injury show that it can improve cognitive function, reduce neuronal loss, and alleviate behavioral deficits.
- Research Significance: Its enhanced activity due to processing makes it a key compound for understanding the benefits of red ginseng and for developing novel ginsenoside-based therapeutics. Human clinical trials are the necessary next step.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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