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Chemicals
Pennogenin CAS NO.507-89-1
<p><strong>Pennogenin</strong> (CAS NO. 507-89-1) is a high-purity, naturally occurring <strong>spirostane-type steroidal sapogenin</strong> derived from various plant species, particularly those in the Liliaceae and Dioscoreaceae families. It is the aglycone (non-sugar) component of steroidal saponins like pennogenin glycosides. This compound is of significant interest in medicinal and pharmacological research due …
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Pennogenin |
| CAS NO. | 507-89-1 |
| Appearance | White to off-white crystalline powder |
| Molecular Formula | C27H42O4 |
| Molecular Weight | 430.62 g/mol |
| Purity (RP-HPLC) | ≥98.0% |
| Solubility | Soluble in chloroform, methanol, ethanol, and DMSO; slightly soluble in water; insoluble in petroleum ether |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Exhibits potential anti-inflammatory, anti-tumor, and neuroprotective properties in preclinical research; serves as a key intermediate in steroid synthesis |
| Storage Conditions | Store in a cool, dry place at 2–8°C, sealed tightly to prevent moisture absorption. Avoid exposure to direct light and high temperatures. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Pennogenin exhibits its diverse biological effects through multiple cellular and molecular pathways. Key mechanisms identified in preclinical studies include:
- Induction of Apoptosis in Cancer Cells: In various cancer cell lines, it triggers mitochondrial-mediated apoptosis by modulating Bcl-2 family proteins, releasing cytochrome c, and activating caspase cascades. It may also inhibit cell proliferation and induce cell cycle arrest.
- Anti-inflammatory Action: It exerts anti-inflammatory effects by inhibiting the NF-κB signaling pathway and downregulating the expression of pro-inflammatory enzymes (e.g., iNOS, COX-2) and cytokines (e.g., TNF-α, IL-6).
- Anti-thrombotic Activity: It has been shown to inhibit platelet aggregation, potentially by interfering with signaling pathways like the PLCγ2-PKC cascade, which may contribute to cardiovascular protection.
- Neuroprotection: Some studies suggest it may protect neuronal cells from oxidative stress and apoptosis, relevant to neurodegenerative disease research.
2.PRODUCT INDICATIONS
This product is indicated for cosmetic science and the formulation of high-performance skincare products focused on brightening, anti-aging, and soothing. Key applications include:
- Skin Brightening & Spot Correcting: Core active in serums, creams, and essences for treating hyperpigmentation, melasma, post-inflammatory hyperpigmentation (PIH), and achieving an even skin tone.
- Anti-Aging & Antioxidant Defense: Used in day creams, serums, and ampoules to protect against environmental aggressors, prevent photoaging, and reduce the appearance of fine lines and wrinkles.
- Soothing & Calming Formulations: Ideal for products designed for sensitive, reactive, or rosacea-prone skin due to its anti-inflammatory properties.
- Supplement to Sun Care: Incorporated into daily moisturizers with SPF to boost protection against oxidative stress caused by UV exposure.
3.CLINICAL EFFICACY OF PRODUCT
Pennogenin is a research compound, and its clinical efficacy in humans has not been established through controlled trials. Its therapeutic potential is supported primarily by a substantial body of in vitro and in vivo preclinical evidence:
- Anti-cancer Potential: Multiple studies report potent cytotoxic activity against a range of human cancer cell lines, with induction of apoptosis and inhibition of tumor growth in animal xenograft models.
- Preclinical Anti-inflammatory Efficacy: Animal models of inflammation (e.g., carrageenan-induced paw edema) show significant anti-inflammatory activity.
- Pharmacological Validation: Its identification as the active aglycone in several traditional medicinal herbs (e.g., Paris polyphylla, Dioscoreaspecies) provides a basis for its ethnopharmacological use and guides modern drug discovery efforts.
- Need for Clinical Translation: While promising, these preclinical findings require rigorous pharmacokinetic, toxicological, and phase I-III clinical studies to evaluate its safety, efficacy, and therapeutic potential in humans.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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If you have any product requirements, please send an email to:business@huanqiukeji9.com;whatsapp:852 7084 6510
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