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Chemicals
GLP-1(7-36) CAS NO.89750-14-1
<p>GLP-1(7-36) is the primary bioactive form of the glucagon-like peptide-1 hormone, a key incretin that plays a central role in glucose metabolism and insulin regulation. This peptide is secreted from intestinal L-cells in response to food intake and is pivotal for maintaining blood glucose homeostasis. It is widely used in research to study type 2 diabetes, obesity, and other metabolic disorders, as well as servin…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | GLP - 1(7 - 36) |
| CAS NO. | 89750 - 14 - 1 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C149H226N40O45 |
| Molecular Weight | 3297.62g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in aqueous buffers such as phosphate - buffered saline (PBS) at appropriate pH values. |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Exhibits potent glucagon - like peptide - 1 receptor agonist activity. It can stimulate insulin secretion in a glucose - dependent manner, inhibit glucagon secretion, slow gastric emptying, and promote satiety, which are key physiological functions related to blood glucose regulation and weight management. |
| Storage Conditions | Store at - 20°C or below in a dry environment, protected from light. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
GLP-1(7-36) exerts its effects by binding to and activating the GLP-1 receptor, a G-protein coupled receptor primarily expressed on pancreatic beta cells. This binding stimulates glucose-dependent insulin secretion, inhibits glucagon release, slows gastric emptying, and promotes satiety in the brain. The activation of downstream signaling pathways, including adenylate cyclase and cAMP production, enhances beta cell proliferation and survival while suppressing apoptosis, collectively improving glycemic control and reducing appetite.
2.PRODUCT INDICATIONS
This product is primarily used in preclinical and clinical research to investigate the pathophysiology and treatment of type 2 diabetes, obesity, and metabolic syndrome. It serves as an essential tool for studying incretin biology, beta cell function, and gastrointestinal motility. Researchers and pharmaceutical developers also utilize it as a critical reference material in the bioassay and development of GLP-1-based therapies, including long-acting agonists and dual/triple receptor co-agonists.
3.CLINICAL EFFICACY OF PRODUCT
In clinical studies, native GLP-1(7-36) has demonstrated significant efficacy in lowering postprandial and fasting blood glucose levels in patients with type 2 diabetes. Its administration leads to enhanced insulin secretion, reduced glucagon levels, and slowed gastric emptying, contributing to improved glycemic control. However, its rapid degradation by dipeptidyl peptidase-4 (DPP-4) limits its therapeutic use, underscoring its role as a benchmark for developing more stable and potent GLP-1 receptor agonists with extended half-lives.
4.Certificate
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
Hot Tags: GLP-1(7-36), GLP-1, Incretin hormone, GLP-1 receptor agonist, Diabetes research, Insulin secretion, Gastric emptying, Satiety hormone, Metabolic peptide, Type 2 diabetes, Obesity research, Beta cell function, DPP-4 substrate, Reference standard, Peptide synthesis, CAS 89750-14-1, Research chemical, Pharmaceutical development, Glucose homeostasis, GLP-1 analog precursor, Liraglutide precursor, Semaglutide standard
If you have any product requirements, please send an email to:sales@huanqiukeji9.com;whatsapp:85244219157
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Global Technology Co., Ltd.
