Mazdutide CAS NO.2259884-03-0

TECHNICAL SPECIFICATIONS

1.MECHANISM OF ACTION

Mazdutide operates through a sophisticated dual-receptor activation mechanism, simultaneously targeting both GLP-1 and glucagon receptors with high specificity and affinity. This dual agonism creates complementary metabolic effects: GLP-1 receptor activation promotes glucose-dependent insulin secretion, inhibits glucagon release, delays gastric emptying, and enhances satiety signaling in the central nervous system. Concurrent glucagon receptor activation stimulates hepatic glucose production and increases energy expenditure while promoting lipid metabolism. The synergistic interaction between these pathways results in enhanced weight reduction, improved glycemic control, and favorable lipid profile modifications that surpass the effects of single-receptor agonists. The compound's engineered structure provides extended circulating half-life through albumin binding, enabling sustained receptor engagement and therapeutic efficacy with convenient dosing intervals.

2.PRODUCT INDICATIONS

Mazdutide is indicated for the treatment of adults with obesity or overweight with at least one weight-related comorbidity, as well as for the management of type 2 diabetes. It is particularly suited for patients who have not achieved sufficient weight loss or glycemic targets with GLP-1 receptor agonist monotherapy and require a more potent metabolic intervention.

3.CLINICAL EFFICACY OF PRODUCT

In Phase 2 clinical trials, Mazdutide demonstrated robust efficacy, with up to 18.6% body weight reduction at the highest dose over 48 weeks in obese non-diabetic patients, significantly outperforming placebo and benchmark GLP-1 drugs. It also showed substantial reductions in liver fat content, improvements in cardiometabolic markers, and a manageable safety profile dominated by transient gastrointestinal events.

Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods 

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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