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Chemicals
Pancreatic Polypeptide, rat CAS NO.90419-12-8
<p>Pancreatic Polypeptide, rat is a highly specific 36-amino acid neuropeptide that serves as a critical research tool for studying the endocrine functions of the pancreas and gastrointestinal tract in rodent models. It is structurally homologous to the human form but exhibits species-specific binding affinity, making it essential for accurate physiological and pharmacological investigations into appetite regulation…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Pancreatic Polypeptide, rat |
| CAS NO. | 90419-12-8 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C195H298N58O57S |
| Molecular Weight | 4398.9g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water or aqueous buffers. For best results, prepare a stock solution in sterile water or PBS and aliquot to avoid repeated freeze-thaw cycles. |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Exhibits biological activity consistent with rat Pancreatic Polypeptide. Specific activity may vary depending on the assay system and experimental conditions. |
| Storage Conditions | Store lyophilized powder at -20°C or below. For long-term storage, keep at -80°C. Protect from light and moisture. Reconstituted solutions should be stored at -20°C or -80°C in single-use aliquots. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
This peptide exerts its effects primarily by binding to Y4 and Y5 receptors in the central nervous system and peripheral tissues, leading to the inhibition of pancreatic exocrine secretion and gastric acid production. Its action is mediated through G-protein coupled receptor signaling, which results in the suppression of vagal tone and modulation of hypothalamic pathways that control satiety and energy expenditure.
2.PRODUCT INDICATIONS
Pancreatic Polypeptide, rat is indicated for use in preclinical research focused on obesity, diabetes, and gastrointestinal motility disorders. It is specifically utilized in rat and mouse models to investigate the role of PP-fold peptides in feeding behavior, to establish dose-response relationships for anti-obesity drugs, and to study the pathophysiology of pancreatic insufficiency.
3.CLINICAL EFFICACY OF PRODUCT
In rodent efficacy studies, administration of this peptide has been shown to significantly reduce food intake and body weight gain without inducing taste aversion or malaise. It demonstrates potent anorexigenic effects in diet-induced obese models, effectively restoring energy balance and improving glycemic control, thereby validating its utility as a benchmark compound for metabolic disease research.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Main Method: International Air Freight
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