Dermorphin CAS NO.77614-16-5

<p>Dermorphin (CAS 77614-16-5) is a highly potent, naturally occurring heptapeptide originally isolated from the skin of South American <em>Phyllomedusa</em>frogs. This synthetic opioid peptide exhibits exceptional μ-opioid receptor (MOR) selectivity and potency, significantly exceeding that of endogenous endorphins and conventional morphine. Manufactured under strict cGMP standards, it serves as a critical res…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Dermorphin
CAS NO.	77614-16-5
Appearance	White to off-white lyophilized powder
Molecular Formula	C40H50N8010
Molecular Weight	802.88g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Soluble in water, dilute acetic acid and aqueous phosphate buffers
Endotoxin	< 1.0 EU/mg
Biological Activity	≥90% relative potency (measured by μ-opioid receptor binding and activation assays).
Storage Conditions	Store at -20°C to -80°C in a dry, dark environment; avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Dermorphin exerts its effects as a highly selective and potent agonist of the μ-opioid receptor (MOR). Upon binding, it activates inhibitory G-proteins (Gi/Go), leading to the inhibition of adenylyl cyclase, reduced cAMP production, hyperpolarization of neurons via potassium efflux, and inhibition of calcium influx. This results in the inhibition of neurotransmitter release (like substance P) in pain pathways and activation of brainstem descending inhibitory pathways, producing powerful analgesia, euphoria, and respiratory depression characteristic of MOR agonism.

2.PRODUCT INDICATIONS

Neuroscience & Pharmacology Research: As a reference compound for studying μ-opioid receptor function, signaling, and ligand-receptor interactions.

Analgesic & Pain Research: Used in animal models to investigate potent analgesia, tolerance development, and opioid side effects.

Comparative Studies: For analyzing structure-activity relationships (SAR) of opioid peptides.

3.CLINICAL EFFICACY OF PRODUCT

Dermorphin is not approved for human therapeutic use. Preclinical animal studies demonstrate its extraordinary analgesic potency, estimated to be 30-40 times more potent than morphine following central administration. While its potency highlights the μ-receptor's role in pain modulation, its clinical development is hindered by significant side effects (severe respiratory depression, high addiction potential, rapid tolerance) and legal restrictions as a controlled substance analogue in many jurisdictions.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.