Dynorphin A (13-17), porcine

<p>Dynorphin A (13-17) is a bioactive fragment of the endogenous neuropeptide Dynorphin A, which is primarily known as a potent and selective agonist of the κ-opioid receptor (KOR). Derived from porcine sources, this fragment is extensively used in research to investigate pain modulation, addiction pathways, and neuroendocrine regulation. Its specificity makes it a valuable tool for studying receptor binding kinetic…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Dynorphin A (13-17), porcine
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C30H43N9O10
Molecular Weight	689.73g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in distilled water (clear solution at 1 mg/mL); soluble in aqueous buffers (PBS, 0.1% TFA); sparingly soluble in organic solvents.
Endotoxin	< 1.0 EU/mg (Typical for research-grade peptides)
Biological Activity	Core C-terminal fragment of the full-length Dynorphin A peptide. Retains affinity for κ-opioid receptors (KOR). Plays a role in modulating pain signaling, neurotransmitter release, and neuronal excitability. Serves as a key structural motif for opioid receptor interaction.
Storage Conditions	Lyophilized powder: Store at -20°C (desiccated) for 12–24 months. Reconstituted solution: Aliquot and store at -20°C; avoid repeated freeze-thaw cycles (stable for 1 month).
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide exerts its effects primarily through binding to the κ-opioid receptor (KOR), which is a G-protein coupled receptor (GPCR). Upon binding, it inhibits adenylate cyclase activity, leading to a reduction in intracellular cAMP levels. Additionally, it modulates calcium and potassium ion channels, resulting in hyperpolarization of neurons and a subsequent decrease in neurotransmitter release. This mechanism underlies its analgesic and neuroprotective properties, distinguishing it from mu-opioid agonists like morphine.

2.PRODUCT INDICATIONS

This product is indicated for scientific research use only. It is utilized in:

Neuroscience Research: Investigating pain pathways, stress responses, and neuroprotection.
Pharmacology: Screening for novel analgesic compounds and studying opioid receptor interactions.
Biochemistry: Analyzing peptide-receptor binding affinity and specificity.
Cell Signaling: Exploring intracellular cascades activated by KOR stimulation.

3.CLINICAL EFFICACY OF PRODUCT

While Dynorphin A fragments are not approved for direct therapeutic use in humans, preclinical studies demonstrate significant analgesic efficacy without the typical euphoric effects associated with mu-opioid agonists. Its selective action on KORs suggests potential for developing non-addictive pain therapeutics and treatments for addiction disorders. Research indicates it may also play a role in modulating mood and stress responses, highlighting its therapeutic potential beyond analgesia.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.