Prolactin Releasing Peptide (12-31), rat CAS NO.222988-10-5

<p>Prolactin Releasing Peptide (12-31), rat is a bioactive fragment of the full-length PrRP, characterized by its high binding affinity to the GPR10 receptor. This synthetic peptide is utilized extensively in scientific research to investigate the mechanisms of prolactin release and its role in neuroendocrine signaling. It is supplied as a lyophilized powder with a purity typically exceeding 90%, ensuring reliable p…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Prolactin Releasing Peptide (12-31), rat
CAS NO.	222988-10-5
Appearance	White to off-white lyophilized powder
Molecular Formula	C104H158N32O26
Molecular Weight	2272.62g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water or aqueous buffers. For best results, prepare a stock solution in sterile water or PBS and aliquot to avoid repeated freeze-thaw cycles.
Endotoxin	< 1.0 EU/mg (Typical for research-grade peptides)
Biological Activity	Exhibits biological activity consistent with the Prolactin Releasing Peptide fragment. Specific activity may vary depending on the assay system and experimental conditions.
Storage Conditions	Store lyophilized powder at -20°C or below. For long-term storage, keep at -80°C. Protect from light and moisture. Reconstituted solutions should be stored at -20°C or -80°C in single-use aliquots.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The peptide exerts its biological effects by binding with high affinity to the G protein-coupled receptor GPR10, which is predominantly expressed in the pituitary gland and specific brain regions. Upon binding, it activates intracellular signaling cascades, leading to the mobilization of calcium ions and the subsequent stimulation of prolactin secretion from lactotroph cells. This mechanism is specific and does not significantly affect the release of other pituitary hormones.

2.PRODUCT INDICATIONS

This product is indicated for use in research applications focused on the endocrine system, particularly in studies involving prolactin regulation, stress responses, and metabolic disorders. It is commonly employed in in vitro assays using cell lines such as CHOK1 or RC-4B/C cells, as well as in vivo studies in rat models to evaluate its effects on hormone secretion and feeding behavior.

3.CLINICAL EFFICACY OF PRODUCT

In preclinical studies, Prolactin Releasing Peptide (12-31), rat has demonstrated efficacy in stimulating a dose-dependent increase in plasma prolactin levels following intravenous administration in rats. It has also shown potential in modulating food intake and body weight in metabolic studies, with female rats often exhibiting greater sensitivity to its effects compared to males, particularly during specific stages of the estrous cycle.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.