Pentapeptide-25 CAS NO.1000313-64-3
<p>Pentapeptide-25 (UCPEPTIDE V) is a synthetic five-amino acid peptide designed to mimic the activity of mitochondrial uncoupling proteins (UCPs) in adipocytes. Supplied as a high-purity white powder for topical cosmetic formulations, it targets lipid metabolism to reduce triglyceride storage and adipocyte size, positioning it as a key ingredient in slimming and body-contouring skincare products.</p>
About this product
Product information from the supplier.
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Pentapeptide-25 |
| CAS NO. | 1000313-64-3 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C14H24N6O4 |
| Molecular Weight | 340.80 g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, phosphate‑buffered saline (PBS), or dilute aqueous solutions. It is recommended to first dissolve in a small volume of sterile water to prepare a 0.1–1.0 mg/mL stock solution. |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Pentapeptide-25 is a synthetic peptide designed to mimic mitochondrial uncoupling protein (UCP) activity. It is used in cosmetic research for its potential lipolytic and body‑contouring effects, acting on adipocytes to promote energy dissipation and reduce triglyceride storage. Bioactivity can be validated in adipocyte‑based assays (e.g., lipolysis measurement). |
| Storage Conditions | Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze‑thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
2.PRODUCT INDICATIONS
3.CLINICAL EFFICACY OF PRODUCT
Pentapeptide-25 lacks robust, peer-reviewed clinical trial data and regulatory approval for therapeutic use. Manufacturer-sponsored studies report modest reductions in thigh circumference and cellulite appearance with topical formulations, but these findings are not substantiated by large, controlled trials. The compound remains a cosmetic ingredient with no established clinical efficacy or safety profile for medical indications.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

What are the benefits of pentapeptide 25?
Pentapeptide-25 is a synthetic bioactive peptide that has gained recognition in the skincare industry for its targeted anti-aging and skin-rejuvenating properties. Structurally, it consists of five amino acids arranged in a specific sequence that allows it to communicate effectively with skin cells, signaling them to perform essential functions that support youthful, healthy skin. One of the primary benefits of Pentapeptide-25 is its ability to reduce the appearance of fine lines and wrinkles. It does this by modulating the activity of neurotransmitters at the neuromuscular junction, which can relax overactive facial muscles that contribute to expression lines. This mechanism is similar to that of botulinum-derived treatments but without injections, offering a non-invasive alternative to achieve smoother and more relaxed skin.
In addition to its wrinkle-reducing effects, Pentapeptide-25 also supports skin repair and regeneration. By stimulating cellular communication, it encourages collagen and elastin production, two critical proteins responsible for skin’s structure, firmness, and elasticity. Increased collagen synthesis helps restore skin’s resilience and reduces sagging, while enhanced elastin promotes flexibility and prevents skin from losing its natural bounce. Over time, these effects contribute to a more youthful and radiant complexion, improving both texture and tone.
Pentapeptide-25 is also valued for its role in maintaining skin hydration and barrier function. By supporting the skin’s natural repair processes and promoting healthy cell turnover, it helps the skin retain moisture more effectively, which is essential for reducing dryness, sensitivity, and irritation. Additionally, it may offer mild antioxidant benefits, helping to protect skin cells from oxidative stress caused by environmental factors like UV radiation and pollution, which are major contributors to premature aging.
This peptide is typically formulated into serums, creams, and other topical skincare products, often in combination with complementary ingredients such as hyaluronic acid, other peptides, or antioxidants to enhance its effectiveness. It is considered gentle and suitable for a wide range of skin types, including sensitive and mature skin. With consistent use, Pentapeptide-25 can deliver gradual yet noticeable improvements in skin smoothness, firmness, and overall youthful appearance, making it a key ingredient in modern anti-aging skincare routines.
In summary, Pentapeptide-25 offers a multi-faceted approach to skin rejuvenation. By relaxing expression-related muscle contractions, stimulating collagen and elastin synthesis, supporting hydration, and providing protective benefits, it helps restore youthful skin function and appearance. Its non-invasive, scientifically backed mode of action makes it an ideal choice for those seeking visible anti-aging results without resorting to surgical or injectable treatments.
What is pentapeptide 25?
Pentapeptide-25 is a synthetic bioactive peptide widely used in skincare and cosmetic formulations for its anti-aging and skin-rejuvenating properties. Chemically, it is composed of a chain of five amino acids (hence “penta-”), which are arranged in a specific sequence to mimic or influence natural biological signals in the skin. Its small size allows it to penetrate the skin effectively, reaching deeper layers where it can interact with skin cells and stimulate beneficial processes.
The primary function of Pentapeptide-25 is to reduce the appearance of fine lines and wrinkles. It works by modulating the signals between nerves and facial muscles, helping to relax overactive muscles that contribute to expression lines, particularly in areas like the forehead, around the eyes, and near the mouth. Unlike injectable treatments such as botulinum toxin, Pentapeptide-25 offers a non-invasive alternative to achieve smoother and more relaxed skin.
Beyond its wrinkle-reducing effect, Pentapeptide-25 also supports skin repair and rejuvenation. It promotes the production of collagen and elastin, essential proteins that maintain the skin’s structure, firmness, and elasticity. Increased collagen helps reduce sagging, while elastin keeps the skin flexible and resilient. Additionally, Pentapeptide-25 can improve skin hydration and barrier function, enhancing the skin’s ability to retain moisture and defend against environmental stressors such as UV radiation and pollution.
Pentapeptide-25 is typically included in serums, creams, and other topical skincare products, often combined with other peptides, antioxidants, or hydrating ingredients to maximize results. It is suitable for a variety of skin types, including sensitive and mature skin, and is known for its gentle yet effective action. Regular use can lead to gradual improvements in skin smoothness, firmness, and overall youthful appearance, making it a popular ingredient in modern anti-aging and restorative skincare routines.
In short, Pentapeptide-25 is a scientifically designed peptide that helps relax facial muscles, stimulate collagen and elastin production, improve hydration, and protect the skin from environmental damage, offering a safe, non-invasive approach to achieving smoother, firmer, and more youthful-looking skin.
What is the main function of peptides?
Peptides are short chains of amino acids, the building blocks of proteins, and their main function in the body and in skincare is to act as messengers that regulate biological processes. In the skin, peptides communicate with cells to stimulate specific responses, such as collagen and elastin production, which are critical for maintaining skin structure, firmness, and elasticity. By signaling skin cells to perform these tasks, peptides help reduce fine lines and wrinkles, improve texture, and support overall skin health.
Beyond structural support, peptides also play a role in repair and regeneration. They can accelerate wound healing, promote cell turnover, and strengthen the skin’s barrier, making it more resilient against environmental stressors such as UV radiation, pollution, and free radicals. Some peptides also have anti-inflammatory or antioxidant properties, helping to calm irritation and protect skin cells from premature aging.
In essence, the main function of peptides is cellular communication and signaling. They tell skin cells what to do, whether it’s producing proteins like collagen, repairing damage, or defending against oxidative stress. This makes them highly versatile and scientifically backed ingredients in skincare formulations, capable of addressing multiple signs of aging, sensitivity, and skin damage, all while being gentle and suitable for various skin types.