Substance P CAS NO.12769-48-1

<p>Substance P is a classic 11-amino acid neuropeptide belonging to the tachykinin family, characterized by its amidated C-terminus which is essential for its high biological activity. It is a key neurotransmitter and neuromodulator widely distributed throughout the central and peripheral nervous systems, functioning as a primary mediator of pain perception, neurogenic inflammation, and various neuroimmune responses…

SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Substance P
CAS NO.	12769-48-1
Appearance	White to off-white lyophilized powder
Molecular Formula	C63H98N18O13S
Molecular Weight	1347.66g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, phosphate-buffered saline (PBS), or dilute acetic acid (e.g., 0.1% v/v). It is recommended to first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution.
Endotoxin	< 1.0 EU/mg (by LAL test, typical for research-grade peptides)
Biological Activity	Binds to and activates the neurokinin-1 receptor (NK1R) with high affinity, inducing calcium mobilization and downstream signaling pathways.
Storage Conditions	Store at -20°C. For long-term storage, store at -80°C. Stable for 12 months under recommended conditions.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The peptide exerts its biological effects primarily by binding with high affinity to the G protein-coupled neurokinin-1 receptor (NK1R). This activates the Gq/11 pathway, stimulating phospholipase C to produce inositol triphosphate and diacylglycerol, leading to a rapid increase in intracellular calcium levels. This signaling cascade triggers neurotransmitter release, smooth muscle contraction, vasodilation, and promotes inflammatory mediator production, thereby mediating its roles in pain transmission, inflammation, and visceral functions.

2.PRODUCT INDICATIONS

Substance P is indicated for a wide range of research applications, including studies of nociception and chronic pain pathways, neurogenic inflammation, migraine pathophysiology, and the brain-gut axis. It is used in vitro for receptor binding and calcium mobilization assays, and in vivo to model inflammatory and pain conditions, investigate anxiety and stress responses, and study the role of neuropeptides in conditions like depression, irritable bowel syndrome, and asthma.

3.CLINICAL EFFICACY OF PRODUCT

While Substance P itself is not a therapeutic agent, its receptor, NK1R, is a validated clinical target. NK1 receptor antagonists, such as aprepitant, are approved and clinically effective for the prevention of chemotherapy-induced nausea and vomiting. Furthermore, extensive research into Substance P pathways has informed the development of investigational therapies for migraine, depression, and chronic pain, though direct infusion of Substance P has shown limited and mixed results in early clinical trials for disorders like major depression.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.