Urocortin II, mouse CAS NO.357952-10-4

<p>Urocortin II, mouse is a 38-amino acid C-terminal amidated neuropeptide that acts as a selective agonist for corticotropin-releasing hormone receptor 2 (CRHR2), supplied as a lyophilized powder with ≥95% HPLC purity and low endotoxin levels. This research-grade peptide exhibits high species specificity for rodent models and is widely used to study stress response pathways, anxiety-like behaviors, and cardiovascul…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Urocortin II, mouse
CAS NO.	357952-10-4
Appearance	White to off-white lyophilized powder
Molecular Formula	C187H320N56O50
Molecular Weight	4152.98g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, phosphate‑buffered saline (PBS), or dilute acetic acid (e.g., 0.1% v/v). It is recommended to first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution.
Endotoxin	< 1.0 EU/mg
Biological Activity	Mouse urocortin II is a selective agonist for the corticotropin‑releasing hormone receptor 2 (CRHR2). It exhibits potent anxiogenic, anorexigenic, and cardiovascular effects, and is involved in stress response and energy homeostasis. Bioactivity can be validated in CRHR2‑expressing cell‑based assays (e.g., cAMP accumulation).
Storage Conditions	Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze‑thaw cycles. For extended stability, store at –80 °C.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Urocortin II, mouse selectively binds to CRHR2 with high affinity, activating Gs-coupled signaling pathways that stimulate adenylate cyclase and increase intracellular cAMP levels. This activation leads to downstream effects including modulation of neurotransmitter release, regulation of hypothalamic-pituitary-adrenal axis activity, and alteration of cardiovascular function through vasodilation and positive inotropy. The peptide exhibits minimal cross-reactivity with CRHR1, making it an ideal tool for studying CRHR2-specific physiological responses such as anxiety, appetite suppression, and stress-induced cardiovascular changes in rodent models.

2.PRODUCT INDICATIONS

This peptide is indicated for research applications focused on stress physiology, anxiety disorders, and cardiovascular function in mouse models. It is utilized in in vitroassays with CRHR2-expressing cells to study cAMP accumulation, receptor binding kinetics, and signal transduction pathways. In in vivostudies, it is administered to investigate anxiety-like behaviors, feeding behavior, thermoregulation, and cardiovascular parameters including blood pressure and heart rate. The product also serves as a reference standard for immunohistochemistry and autoradiography to localize CRHR2 expression in brain regions and peripheral tissues involved in stress response and metabolic regulation.

3.CLINICAL EFFICACY OF PRODUCT

Urocortin II, mouse has no clinical efficacy or safety profile, as it is strictly a research reagent for preclinical investigations in rodent models. The peptide has not undergone clinical trials, regulatory evaluation, or safety assessment for diagnostic or therapeutic use in humans. While preclinical studies demonstrate its potent effects on stress response and cardiovascular function in mice, these findings remain exploratory and have not been translated into validated clinical interventions. Any potential therapeutic applications would require the development of species-appropriate agents with comprehensive pharmacokinetic and safety evaluations.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight

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