Biotinyl-MCH (salmon)

<p>Biotinyl-MCH (salmon) is a biotinylated analog of salmon Melanin-Concentrating Hormone, where a biotin moiety is attached to the N-terminus via a spacer. This modification preserves the peptide's native receptor-binding activity while enabling its detection, purification, and immobilization through the high-affinity streptavidin-biotin interaction, making it a versatile research tool for studying MCH receptor…

SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Biotinyl-MCH (salmon)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C99H153N29O26S5
Molecular Weight	2325.82g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, phosphate-buffered saline (PBS), or dilute acetic acid (e.g., 0.1% v/v). It is recommended to first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution.
Endotoxin	< 1.0 EU/mg (by LAL test, typical for in vitro applications).
Biological Activity	Binds to melanin-concentrating hormone receptors (MCHR1/MCHR2) with high affinity, retaining the biological activity of native MCH. The biotin tag allows for detection, purification, or immobilization via streptavidin-biotin interaction.
Storage Conditions	Store at -20°C. For long-term storage, store at -80°C. Protect from light and moisture. Reconstituted solutions should be aliquoted and stored at -20°C or -80°C to avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The peptide functions as an agonist at G protein-coupled melanin-concentrating hormone receptors (MCHR1 and MCHR2). Upon binding, it activates Gi/o signaling, inhibiting adenylyl cyclase and reducing intracellular cAMP levels, which modulates neuronal activity, food intake, and energy homeostasis. The biotin tag does not interfere with receptor engagement but facilitates downstream applications like pull-down assays and receptor localization studies.

2.PRODUCT INDICATIONS

Biotinyl-MCH (salmon) is indicated for research applications in neurobiology, endocrinology, and metabolism, including receptor binding and internalization assays, immunohistochemical localization of MCH receptors, affinity purification of receptor complexes, and studies of MCH's role in feeding behavior, sleep regulation, and emotional states. It is suitable for both in vitro biochemical studies and ex vivo tissue analysis.

3.CLINICAL EFFICACY OF PRODUCT

As a research-grade biotinylated probe, Biotinyl-MCH (salmon) has no established clinical efficacy or therapeutic use. Its utility lies in preclinical research, where it enables the characterization of MCH receptor biology and the validation of MCH as a therapeutic target for obesity, anxiety, and sleep disorders, informing the development of potential clinical candidates but not serving as a drug itself.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.