Atriopeptin I (rat) CAS NO.89139-53-7

<p>Atriopeptin I (rat) is a high-purity synthetic peptide fragment corresponding to the 25-amino acid sequence (residues 1-25) of rat Atrial Natriuretic Peptide (ANP). As a key member of the natriuretic peptide family, it serves as a crucial research tool for studying cardiovascular and renal physiology. This well-characterized peptide, with a molecular weight of approximately 2801.2 g/mol and typical purity exceedi…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Atriopeptin I (rat)
CAS NO.	89139-53-7
Appearance	White to off-white lyophilized powder
Molecular Formula	C83H135N29O30S2
Molecular Weight	2083.31g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water or aqueous buffers (e.g., PBS, pH 7.2-7.4). For higher concentrations, initial dissolution in a minimal amount of dilute acetic acid or acetonitrile/water mixture is recommended.
Endotoxin	< 1.0 EU/mg
Biological Activity	Atriopeptin I (rat) corresponds to atrial natriuretic peptide (ANP) fragment 1-25. It binds to natriuretic peptide receptors (NPR-A/GC-A), stimulating cGMP production, and is used to study cardiovascular regulation, blood pressure, renal function, and natriuresis in rodent models.
Storage Conditions	Store desiccated at -20°C or below for long-term stability. Avoid repeated freeze-thaw cycles of reconstituted solutions. Protect from light.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Atriopeptin I (rat) exerts its biological effects by binding to and activating the natriuretic peptide receptor-A (NPR-A/GC-A), a guanylyl cyclase-coupled receptor. This binding triggers the intracellular conversion of GTP to cyclic GMP (cGMP), serving as a critical second messenger. The resulting elevation in cGMP levels leads to the relaxation of vascular smooth muscle, promotion of renal sodium and water excretion (natriuresis and diuresis), and inhibition of the renin-angiotensin-aldosterone system, collectively contributing to blood pressure reduction and fluid homeostasis.

2.PRODUCT INDICATIONS

This product is specifically indicated for preclinical research in cardiovascular and renal pharmacology. It is used extensively in vitro and in vivo to model ANP pathway activity, study mechanisms of hypertension and heart failure, and evaluate renal function. Researchers utilize Atriopeptin I (rat) in assays involving isolated blood vessels, kidney perfusion studies, cell culture systems, and animal models to dissect the pathophysiology of cardiovascular diseases and screen for potential therapeutic agents targeting the natriuretic peptide system.

3.CLINICAL EFFICACY OF PRODUCT

In experimental research settings, Atriopeptin I (rat) has demonstrated potent efficacy in eliciting characteristic physiological responses, including vasodilation, diuresis, and natriuresis in rat models. Studies consistently show its ability to lower blood pressure and modulate fluid-electrolyte balance, validating its bioactivity and reliability as a reference standard. Its use has been instrumental in defining the ANP pathway's role, providing a robust foundation for translational research aimed at developing novel treatments for conditions like hypertension and congestive heart failure.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Main Method: International Air Freight

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