Amyloid β/A4 Protein Precursor₇₇₀ (394-410) trifluoroacetate salt/APP₇₇₀ (394-410) CAS NO.148914-01-6

<p>Amyloid β/A4 Protein Precursor₇₇₀ (394-410) trifluoroacetate salt is a high-purity synthetic peptide fragment corresponding to residues 394-410 of the human amyloid-beta precursor protein (APP₇₇₀ isoform). This sequence is located within the extracellular domain of APP, a key protein involved in Alzheimer's disease pathology. Supplied as a lyophilized powder with typical purity >95%, it serves as an essent…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Amyloid β/A4 Protein Precursor₇₇₀ (394-410) trifluoroacetate salt/APP₇₇₀ (394-410)
CAS NO.	148914-01-6
Appearance	White to off-white lyophilized (freeze-dried) powder.
Molecular Formula	C86H151N31O26S2
Molecular Weight	2099.47g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water or aqueous buffers (e.g., PBS) at low concentration. For higher concentrations, initial dissolution in a minimal amount of dilute acetic acid or DMSO is recommended, followed by dilution with the desired aqueous buffer.
Endotoxin	< 1.0 EU/mg
Biological Activity	This synthetic peptide corresponds to amino acids 394-410 of the human Amyloid-β A4 Precursor Protein (APP₇₇₀ isoform). It is commonly used as an antigen for antibody production and in immunological studies to investigate APP processing, amyloid-β formation, and Alzheimer's disease-related research.
Storage Conditions	Store desiccated at -20°C or below for long-term stability. Avoid repeated freeze-thaw cycles of reconstituted solutions.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide fragment acts primarily as a specific antigenic target or a molecular probe in experimental settings. Its sequence is recognized by antibodies raised against APP, allowing it to be used in immunoassays like ELISA and Western Blot to detect APP expression or cleavage. In functional studies, it can potentially interfere with or modulate interactions between APP and its processing enzymes (e.g., BACE1, γ-secretase), providing insights into the proteolytic events that lead to the production of neurotoxic amyloid-beta peptides.

2.PRODUCT INDICATIONS

This product is indicated for use in foundational neuroscience and Alzheimer's disease research. Its primary applications include the generation and characterization of polyclonal and monoclonal antibodies specific to the APP protein. It is also employed in epitope mapping studies, as a blocking agent in immunohistochemistry, and as a standard or control in assays designed to investigate APP metabolism, protein-protein interactions, and the molecular pathways contributing to amyloid plaque formation.

3.CLINICAL EFFICACY OF PRODUCT

In a research context, APP₇₇₀ (394-410) demonstrates high efficacy as a well-defined immunological reagent. Studies utilizing this peptide have successfully generated specific antisera with strong reactivity to native APP, enabling sensitive detection and quantification in biological samples. Its use has contributed to elucidating APP's role in disease models, validating its utility as a critical component for advancing diagnostic development and therapeutic target validation in neurodegenerative disease research.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.