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Chemicals
Amylin,human CAS NO.122384-88-7
<p><strong>Amylin, human</strong> (CAS NO. 122384-88-7) is a synthetic 37-amino acid peptide hormone, also known as <strong>Islet Amyloid Polypeptide (IAPP)</strong>. It is co-secreted with insulin by the pancreatic β-cells in response to meals. This research-grade peptide is a critical endogenous regulator of glucose homeostasis, gastric emptying, and satiety. It plays a significant role in the pathophysiology of t…
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Amylin, human |
| CAS NO. | 122384-88-7 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₁₆₅H₂₆₁N₅₁O₅₅S₂ |
| Molecular Weight | 1067.21 g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water (5 mg/mL) or 5% acetic acid; also soluble in DMSO |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Endogenous peptide agonist for amylin, calcitonin, CGRP, and adrenomedullin receptors; inhibits glucagon secretion, delays gastric emptying, and acts as a satiety agent with glucose-lowering effects in vivo. |
| Storage Conditions | 20°C for long-term storage ; avoid repeated freeze-thaw cycles. Store as aliquots in sealed vials. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Amylin exerts its physiological effects primarily by activating specific amylin receptors, which are complexes of the Calcitonin Receptor (CTR) and Receptor Activity-Modifying Proteins (RAMPs). Its key mechanisms include:
- Inhibition of Glucagon Secretion: Amylin acts on the pancreas to suppress postprandial glucagon secretion from α-cells, reducing hepatic glucose production.
- Slowing of Gastric Emptying: It acts centrally via receptors in the area postrema to delay the rate of gastric emptying, which moderates the post-meal rise in blood glucose.
- Promotion of Satiety: By signaling to the brain (particularly the hindbrain and hypothalamus), amylin induces a feeling of fullness (satiety), leading to reduced food intake.
- Potential Pathological Aggregation: In type 2 diabetes, human amylin can form toxic oligomers and amyloid fibrils, which contribute to β-cell dysfunction and apoptosis—a process actively studied in diabetes research.
2.PRODUCT INDICATIONS
This product is indicated for advanced research in endocrinology, diabetes, metabolism, and neuroscience. Key applications include:
- Diabetes & Metabolism Research: Studying the role of amylin in normal glucose homeostasis and its dysfunction in type 1 and type 2 diabetes.
- Obesity & Satiety Studies: Investigating its anorexigenic effects and potential as a target for weight management.
- Amyloid & Protein Aggregation Research: As a model peptide for studying the mechanisms of amyloid formation, β-cell toxicity, and its link to diabetes pathology.
- Pharmacology & Drug Discovery: Serving as a reference compound for screening and developing amylin receptor agonists or analogs (e.g., pramlintide).
- Physiological Studies: Research on gastrointestinal motility and hormonal cross-talk in metabolism.
3.CLINICAL EFFICACY OF PRODUCT
Human amylin itself is not used therapeutically due to its propensity to aggregate and poor solubility. However, its clinical significance is profound:
- Therapeutic Analog (Pramlintide): The knowledge of amylin's physiology directly led to the development of pramlintide, a stable, non-aggregating analog. Pramlintide is an FDA-approved adjunct therapy for type 1 and type 2 diabetes. It effectively:
- Reduces postprandial blood glucose levels.
- Lowers HbA1c.
- Promotes weight loss by enhancing satiety.
- Biomarker & Pathological Role: Amylin (IAPP) is a key biomarker and pathological agent in diabetes research. Studying this peptide is essential for understanding disease mechanisms and identifying new therapeutic strategies.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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