Type A Allatostatin I CAS NO.123338-10-3

Type A Allatostatin I (often abbreviated as AST-A I) is a synthetic neuropeptide belonging to the Allatostatin A family. This family of peptides is evolutionarily conserved in insects and crustaceans, where they play critical roles as inhibitory regulators. Type A Allatostatins are primarily known for their ability to inhibit the biosynthesis of …

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Type A Allatostatin I
CAS NO.	123338-10-3
Appearance	White to off-white lyophilized powder
Molecular Formula	C₆₁H₉₄N₁₈O₁₆
Molecular Weight	1335.51 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water (≥5 mg/ml), DMSO, dilute aqueous buffers (PBS, Tris‑HCl, pH 7.0-8.0); Slightly soluble in methanol/ethanol.
Endotoxin	< 1.0 EU/mg
Biological Activity	Tridecapeptide neuropeptide; potent inhibitor of juvenile hormone (JH) synthesis by insect corpora allata; modulates insect development, reproduction, and feeding; research tool for insect endocrinology, pest control target validation, and neuropeptide signaling studies
Storage Conditions	Store at -20°C to -80°C in a dry, dark, sealed environment; avoid repeated freeze‑thaw cycles (aliquot for single use); short‑term storage (≤2 weeks) at 2-8°C.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Type A Allatostatin I exerts its effects by binding to specific G protein-coupled receptors (GPCRs) on target cells. The canonical mechanism involves:

Receptor Binding: The peptide binds with high affinity to Allatostatin A receptors (AST-ARs) present on the membrane of endocrine cells, such as those in the corpora allata, and neurons.
Inhibition of Adenylate Cyclase: Receptor activation typically couples to Gi/o proteins, leading to the inhibition of adenylate cyclase. This results in a decrease in intracellular cyclic AMP (cAMP) levels.
Suppression of Juvenile Hormone Synthesis: In the corpora allata, the drop in cAMP and associated signaling cascades directly inhibits the enzymes and pathways required for the biosynthesis of juvenile hormone (JH). JH is a key hormone that promotes juvenile characteristics and vitellogenesis (yolk production).
Neuromodulation: In the nervous system, AST-As act as inhibitory neurotransmitters or neuromodulators, affecting muscle contraction (especially gut motility), neural excitability, and other physiological processes.

2.PRODUCT INDICATIONS

This product is indicated for fundamental and applied research in invertebrate biology and pest management. Key applications include:

Insect Endocrinology & Physiology: Studying the regulation of juvenile hormone titers, metamorphosis, reproduction (vitellogenesis), and diapause.
Neurobiology: Investigating the role of allatostatins as inhibitory neurotransmitters/modulators in the insect central and stomatogastric nervous systems, particularly their myoinhibitory effects on gut and heart muscle.
Comparative Zoology: Exploring the evolution of neuropeptide systems across arthropods.
Integrated Pest Management (IPM) Research: As a lead compound for developing novel, species-specific insect growth regulators (IGRs) that disrupt development and reproduction without affecting non-target organisms.

3.CLINICAL EFFICACY OF PRODUCT

Type A Allatostatin I is not a clinical therapeutic for humans or vertebrates. Its "efficacy" is defined in the context of basic science and agricultural biotechnology.

Validated Biological Activity: It is a proven, potent inhibitor of JH biosynthesis in multiple insect species, with clear effects on development and reproduction in experimental models.
Research Tool Efficacy: It is an indispensable reagent for mapping neuroendocrine circuits and understanding the hormonal control of insect life cycles.
Therapeutic Potential in Pest Control: Research using this peptide provides the foundational knowledge required to design stable peptide analogs, mimetics, or receptor-targeting agents that could serve as next-generation, environmentally friendly biorational pesticides. Its high specificity for insect systems makes it an attractive template for such development.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.