AGRP (54-82)

AGRP (54-82) is a synthetic peptide fragment corresponding to the C-terminal portion (residues 54-82) of the full-length human Agouti-Related Protein (AGRP). This research-grade peptide represents a structurally disordered, cysteine-rich region of AGRP, distinct from the N-terminal active core. It serves as a critical control, epitope mapping tool, or structural probe in studies …

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	AGRP (54-82)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₄₁H₂₃₈N₄₆O₃₂S
Molecular Weight	3022.76 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water (≥5 mg/ml), DMSO, and dilute aqueous buffers.
Endotoxin	< 1.0 EU/mg
Biological Activity	Potent antagonist of melanocortin receptors (MC1R, MC3R, MC4R, MC5R); modulates energy homeostasis, feeding behavior, and pigmentation; used as a research tool for metabolic and neurobiology studies
Storage Conditions	Store at -20°C to -80°C in a dry, dark, sealed environment; avoid repeated freeze-thaw cycles; aliquot for single use.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Unlike the N-terminal fragment (AGRP 25-51), the C-terminal AGRP (54-82) fragment itself lacks the structured, bioactive loop responsible for high-affinity antagonism at melanocortin receptors (MC3R/MC4R). Therefore, its primary utility is not direct receptor modulation. Its mechanisms relate to its role in the full-length protein:

Structural Role in Full-Length AGRP: In the native protein, this cysteine-rich domain is involved in forming disulfide bonds that stabilize the overall structure, potentially influencing the presentation and folding of the active N-terminal loop.
Research Probe: It is primarily used as a negative control or specificity control in experiments testing the effects of the active AGRP fragment. Its lack of receptor activity confirms that observed biological effects are due to the specific active site, not non-specific peptide interactions.
Antigenic Epitope: The sequence can be used to generate antibodies specific to the C-terminus of AGRP for detection, localization, or quantification studies of the prohormone or its processing.

2.PRODUCT INDICATIONS

This product is indicated for specialized, foundational research in neuropeptide biochemistry and molecular pharmacology. Key applications include:

As a critical negative control in experiments investigating the effects of AGRP on feeding behavior, energy homeostasis, or melanocortin receptor signaling. Its use validates that effects are specific to the active receptor-binding domain.
In studies of AGRP protein structure, folding, and disulfide bond formation.
For epitope mapping and antibody generation to distinguish between different regions of the AGRP protein or its cleavage products.
In research on the post-translational processing and maturation of the AGRP prohormone.
As a tool in assay development and validation (e.g., ELISA, Western blot) to ensure specificity for the active fragment versus other regions.

3.CLINICAL EFFICACY OF PRODUCT

AGRP (54-82) itself has no direct clinical efficacy as a therapeutic or diagnostic. Its immense value is in ensuring scientific rigor and validity in preclinical research. By providing a well-defined inactive fragment, it allows researchers to:

Definitively attribute physiological effects (like increased food intake) to the specific antagonism of melanocortin receptors by the active AGRP core, strengthening the evidence base.
Avoid misinterpretation of data that could arise from non-specific effects of peptide administration.
Support the high-quality, reproducible science that underpins translational drug discovery. The clear distinction between active and inactive regions of AGRP was crucial for rationally designing melanocortin receptor-targeted drugs (like setmelanotide).

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.