SH2 Domain Ligand (3)

<p>SH2 Domain Ligand (3) is a high-purity peptide or peptidomimetic research tool designed to selectively target a specific SH2 domain, supplied as a lyophilized powder for biochemical and cellular studies. It enables precise modulation of SH2-mediated protein-protein interactions, serving as a critical reagent for investigating signal transduction pathways, kinase signaling networks, and molecular mechanisms underl…

SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com

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Peptides

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	SH2 Domain Ligand (3)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C82H122N15O27PS
Molecular Weight	1813.03g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, phosphate‑buffered saline (PBS), or dilute aqueous solutions. Recommended to dissolve in sterile water or suitable buffer to prepare a 0.1–1.0 mg/mL stock solution.
Endotoxin	< 1.0 EU/mg
Biological Activity	SH2 Domain Ligand (3) is a peptide or peptidomimetic designed to bind with high affinity and selectivity to a specific SH2 domain (e.g., Src, Grb2, PI3K, etc.). It is used in biochemical and cellular assays to study SH2‑mediated protein‑protein interactions, signal transduction pathways, and as a tool for inhibitor screening. Activity is validated by SH2 domain binding assays (e.g., SPR, competitive ELISA).
Storage Conditions	Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze‑thaw cycles. For extended stability, store at –80 °C.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This ligand functions by competitively binding to the phosphotyrosine recognition pocket of its target SH2 domain, disrupting the natural interaction between the SH2-containing protein and its phosphorylated binding partners. This blockade prevents the recruitment of downstream effector proteins to activated receptors or scaffolds, thereby inhibiting specific signaling cascades such as PI3K/AKT, Src family kinase pathways, or other SH2-dependent networks without directly affecting catalytic kinase activity, allowing for clean mechanistic dissection of pathway dependencies.

2.PRODUCT INDICATIONS

SH2 Domain Ligand (3) is indicated for research use in studying SH2 domain biology, including competitive binding assays (SPR, ITC, ELISA), cellular pathway inhibition experiments, high-throughput screening for SH2 domain inhibitors, and validation of SH2-dependent phenotypes in cancer models, immune cell activation, and developmental signaling. It is suitable for in vitro biochemical characterization and cell-based functional studies across academic, pharmaceutical, and biotechnology research settings.

3.CLINICAL EFFICACY OF PRODUCT

As a research tool compound, SH2 Domain Ligand (3) is not intended for clinical application and has no established human efficacy data. Preclinical studies demonstrate its utility as a pharmacological probe to validate specific SH2 domains as therapeutic targets, showing dose-dependent inhibition of SH2-mediated signaling events, reduced downstream pathway activation, and modulation of cellular phenotypes in proof-of-concept experiments, supporting its role in drug discovery and target validation pipelines rather than direct therapeutic use.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.