AGRP (25-51) CAS NO.209460-61-7

AGRP (25-51) is a synthetic peptide fragment corresponding to amino acid residues 25-51 of the full-length Agouti-Related Protein (AGRP). AGRP is an endogenous neuropeptide primarily expressed in the hypothalamus. This research-grade peptide acts as a potent and selective endogenous antagonist of the melanocortin receptors MC3R and MC4R. It is a critical tool for studying energy …

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	AGRP (25-51)
CAS NO.	209460-61-7
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₃₀H₂₂₁N₃₇O₃₅S
Molecular Weight	2894.44 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water (≥5 mg/ml), DMSO, and dilute aqueous buffers (e.g., PBS, pH 7.4)
Endotoxin	≤50 EU/mg
Biological Activity	Amino-terminal fragment of AGRP; inhibits norepinephrinergic neurons in the locus coeruleus; modulates norepinephrine biosynthesis and neurotransmission; research tool for studying feeding behavior, energy metabolism, and neurological regulation
Storage Conditions	Store at -20°C in a dry, dark environment; avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

AGRP (25-51) functions as a competitive inverse agonist/antagonist at the melanocortin 3 and melanocortin 4 receptors (MC3R and MC4R).

Receptor Antagonism: The peptide binds to MC3R and MC4R with high affinity, directly competing with endogenous agonist neuropeptides like α-MSH for the receptor binding site. Upon binding, it blocks the receptor's activation.
Inverse Agonism: Evidence suggests that AGRP may also act as an inverse agonist at these receptors. This means it can actively suppress the receptor's basal (constitutive) activity, pushing the signaling pathway towards an "off" state beyond simple blockade.
Downstream Effect on Feeding: In the brain, antagonism of the MC4R (primarily) and MC3R in the arcuate nucleus disinhibits feeding circuits. This blockade of the anorexigenic (appetite-suppressing) melanocortin pathway leads to a potent stimulation of food intake and a reduction in energy expenditure.

2.PRODUCT INDICATIONS

This product is indicated for advanced in vitro and in vivo research in neuroendocrinology, metabolism, and pharmacology. Key applications include:

Studying the physiological and pathophysiological roles of the central melanocortin system in regulating body weight, food intake, and energy balance.
As a selective pharmacological tool to antagonize MC3R/MC4R in order to dissect their specific functions in animal models of obesity and metabolic disorders.
Investigating the mechanisms of action of anti-obesity drugs that target the melanocortin pathway.
Serving as a reference antagonist in receptor binding assays and functional studies (e.g., cAMP assays) to characterize MC3R and MC4R ligands and screen for novel agonists/antagonists.
Research into conditions involving cachexia or anorexia, where modulating this pathway may be therapeutic.

3.CLINICAL EFFICACY OF PRODUCT

AGRP (25-51) is a preclinical research tool, not a human therapeutic. However, its profound biological effects have made it instrumental in validating the melanocortin pathway as one of the most critical therapeutic targets for obesity. Research using this peptide has:

Definitively proven that blocking central MC4R signaling is a powerful driver of hyperphagia and weight gain.
Provided the foundational rationale for the development of MC4R agonists (e.g., setmelanotide) as treatments for rare genetic obesity disorders like POMC and LEPR deficiency. Understanding the antagonist (AGRP) solidified the agonist strategy.
Advanced the basic science of appetite regulation, directly impacting drug discovery efforts for metabolic diseases.

4.DELIVERY & SHIPPING

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Main Method: International Air Freight

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