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Chemicals
Nonapeptide-1 CAS NO.158563-45-2
<p><strong>Nonapeptide-1</strong> is a synthetic nine-amino acid peptide specifically engineered for advanced cosmetic and dermatological applications, with a primary focus on <strong>inhibiting melanogenesis</strong> (the production of melanin). This biomimetic peptide is designed to target and regulate key pathways responsible for skin pigmentation, making it a potent active ingredient in formulations aimed at red…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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About this product
Product information from the supplier.
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Nonapeptide-1 |
| CAS NO. | 158563-45-2 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₅₁H₇₁N₁₅O₁₁S₂ |
| Molecular Weight | 1142.34g/mol |
| Purity (RP-HPLC) | ≥98.0% |
| Solubility | Soluble in water (≥20 mg/mL), soluble in dilute acetic acid or DMSO |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Melanogenesis inhibitor; competitively binds to melanocortin 1 receptor (MC1R) to reduce UV-induced pigmentation; used in skin brightening formulations |
| Storage Conditions | Store at -20°C to -8°C in a dry, dark environment; avoid repeated freeze-thaw cycles |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Nonapeptide-1 functions through a highly targeted signaling mechanism to control excess melanin production at the transcriptional level:
- Inhibition of α-MSH Signaling: The peptide is designed to act as a competitive antagonist to α-Melanocyte-Stimulating Hormone (α-MSH). It binds to the Melanocortin-1 Receptor (MC1R) on the surface of melanocytes, blocking the binding of α-MSH.
- Downregulation of Key Melanogenic Factors: By blocking this critical signal, Nonapeptide-1 prevents the activation of the intracellular cAMP/PKA pathway. This leads to the downregulation of Microphthalmia-associated Transcription Factor (MITF), the master regulator of melanogenesis.
- Reduced Enzyme Production: With lower MITF activity, the expression of key melanogenic enzymes, most notably tyrosinase, as well as TYRP1 and TYRP2, is significantly decreased.
- Suppressed Melanin Synthesis: The overall reduction in these enzymes results in a direct and potent inhibition of melanin synthesis within the melanocyte, effectively lightening pigmentation.
2.PRODUCT INDICATIONS
This product is indicated for cosmetic science and the formulation of high-efficacy skin-brightening and pigment-correcting products. Key applications include:
- As a primary active in professional-grade brightening serums, creams, and spot treatments for melasma, post-inflammatory hyperpigmentation (PIH), and solar lentigines (sun spots).
- In formulations designed to achieve an even skin tone and reduce the appearance of freckles and age-related hyperpigmentation.
- For corrective treatments targeting stubborn or recurring dark spots.
- As a key component in comprehensive anti-aging regimens that address photoaging signs like uneven pigmentation.
- In products aimed at preventing UV-induced or hormonal pigmentation.
3.CLINICAL EFFICACY OF PRODUCT
Nonapeptide-1 is supported by in vitro data demonstrating its potent inhibitory effect on melanin production and by clinical studies on cosmetic formulations. Evidence confirms its high efficacy as a skin-brightening agent:
- Significant Reduction in Pigmentation: Clinical trials show a visible and measurable lightening of hyperpigmented areas and an overall improvement in skin tone evenness.
- High Potency: It is recognized as one of the most effective peptide-based brighteners due to its upstream, receptor-level mechanism of action.
- Favorable Safety Profile: Its targeted biological action often results in lower irritation potential compared to some chemical inhibitors, making it suitable for longer-term use and sensitive skin.
- Improved Skin Radiance: Regular use contributes to a brighter, more luminous, and uniform complexion.
GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.
4.Certificate
Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.
We prioritize:
1.A rigorous quality management system
2.Batch traceability and stability data
3.Professional laboratory testing and validation
4.Compliance with international trade standards
Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.
5.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.
We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.
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If you have any product requirements, please send an email to:business@huanqiukeji9.com;whatsapp:852 7084 6510
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Global Technology Co., Ltd.
