VIP, human, porcine, rat; VIP (28 amino acids) CAS NO.40077-57-4

<p>VIP, human, porcine, rat is a 28-amino acid neuropeptide that is conserved across these three species, featuring a C-terminal amidation essential for its biological activity. This high-purity research reagent is supplied as a lyophilized powder and functions as a potent agonist for VPAC1 and VPAC2 receptors. It is widely used to study gastrointestinal motility, respiratory function, immune modulation, and neuroen…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	VIP, human, porcine, rat; VIP (28 amino acids)
CAS NO.	40077-57-4
Appearance	White to off-white lyophilized powder
Molecular Formula	C147H238N44O42S
Molecular Weight	3225.7g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, phosphate‑buffered saline (PBS), or dilute acetic acid (e.g., 0.1% v/v). It is recommended to first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution.
Endotoxin	< 1.0 EU/mg
Biological Activity	VIP is a 28‑aa neuropeptide that acts as a potent agonist for VPAC1 and VPAC2 receptors. It mediates a wide range of physiological effects, including vasodilation, bronchodilation, immune modulation, and neurotransmission. Bioactivity is typically confirmed by receptor binding assays (e.g., competition with radiolabeled VIP) or functional assays (e.g., cAMP accumulation in VPAC‑expressing cells).
Storage Conditions	Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze‑thaw cycles. For extended stability, store at –80 °C
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

VIP exerts its effects by binding with high affinity to VPAC1 and VPAC2 receptors, coupling to Gs proteins to stimulate adenylate cyclase and increase intracellular cAMP levels. This signaling cascade leads to smooth muscle relaxation, vasodilation, bronchodilation, and modulation of immune cell function and neurotransmitter release. The peptide's conserved structure across human, porcine, and rat models ensures consistent receptor activation, making it a reliable tool for studying cAMP-mediated pathways in diverse physiological contexts.

2.PRODUCT INDICATIONS

This peptide is indicated for research applications investigating gastrointestinal disorders, respiratory diseases, immune regulation, and neuroendocrine function. It is utilized in in vitroassays with VPAC receptor-expressing cells to study cAMP accumulation, receptor binding, and downstream signaling. In in vivostudies, it is administered to model systems to investigate effects on smooth muscle relaxation, inflammation, and neuronal activity. The product also serves as a reference standard for receptor autoradiography, immunohistochemistry, and functional studies exploring VIP's role in conditions such as irritable bowel syndrome, asthma, and autoimmune disorders.

3.CLINICAL EFFICACY OF PRODUCT

VIP, human, porcine, rat has no established clinical efficacy or safety profile, as it is strictly a research reagent for preclinical investigations. The peptide has not undergone clinical trials, regulatory evaluation, or safety assessment for diagnostic or therapeutic use. While preclinical studies demonstrate its potential in modulating smooth muscle tone, inflammation, and secretory processes, these findings remain exploratory. Any clinical translation would require the development of stable formulations or analogs with comprehensive pharmacokinetic and safety evaluations.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.