[Arg8]-Vasopressin (4-9) CAS NO.96027-30-4

<p>[Arg⁸]-Vasopressin (4-9) is a synthetic, six-residue cyclic peptide fragment corresponding to the 4-9 region of [Arg⁸]-Vasopressin, featuring an intramolecular disulfide bond essential for maintaining the bioactive conformation. This research-grade analog is supplied as a lyophilized powder with guaranteed high purity, designed for structure-activity relationship (SAR) studies and investigations into the core pha…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Arg8]-Vasopressin (4-9)
CAS NO.	96027-30-4
Appearance	White to off-white lyophilized powder
Molecular Formula	C25H44N12O8S
Molecular Weight	672.76g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, phosphate‑buffered saline (PBS), or dilute acetic acid (e.g., 0.1% v/v). It is recommended to first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution.
Endotoxin	< 1.0 EU/mg
Biological Activity	This fragment corresponds to the core cyclic region of [Arg⁸]-Vasopressin. It may retain partial binding affinity for vasopressin receptors (V1a/V2) and is used in structure-activity relationship (SAR) studies to investigate the pharmacophore of vasopressin. Bioactivity should be validated in receptor binding or functional assays.
Storage Conditions	Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze‑thaw cycles. For extended stability, store at –80 °C
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The peptide exerts its effects by binding to vasopressin receptor subtypes (V1a, V1b, V2) with an affinity profile that reflects its role as a core receptor-interacting fragment. Engagement with these G protein-coupled receptors can modulate downstream signaling pathways, such as phospholipase C activation (leading to calcium mobilization) or adenylate cyclase stimulation (resulting in cAMP accumulation), depending on the receptor subtype and cellular context. The cyclic disulfide structure is critical for this interaction, mimicking the bioactive conformation of the native hormone's ring, making it a valuable probe for studying receptor-ligand recognition and the molecular basis of vasopressin's physiological effects.

2.PRODUCT INDICATIONS

[Arg⁸]-Vasopressin (4-9) is indicated exclusively for research applications in pharmacology, neuroendocrinology, and drug discovery. It is primarily used in structure-activity relationship studies to map essential residues for vasopressin receptor binding, in competitive binding assays to characterize receptor subtypes, and in functional screenings to identify novel modulators of the vasopressin system. This fragment is also employed in biophysical studies to understand peptide-receptor interactions and in the development of vasopressin-based diagnostic tools or therapeutic leads.

3.CLINICAL EFFICACY OF PRODUCT

As a research reagent, [Arg⁸]-Vasopressin (4-9) has no established clinical efficacy or safety profile for therapeutic use in humans. The peptide has not undergone clinical trials, regulatory evaluation, or safety assessment for any medical indication. Its utility is confined to preclinical laboratory research aimed at advancing the fundamental understanding of vasopressin biology and facilitating the rational design of future therapeutics. Any potential clinical translation would require the development of distinct drug candidates derived from such research, subject to comprehensive preclinical and clinical development pathways.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight

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