Biotin-(Arg8)-Vasopressin CAS NO.126703-17-1

<p>Biotin-(Arg⁸)-Vasopressin is a biotin-conjugated analog of Arg⁸-vasopressin, supplied as a lyophilized powder with ≥95% HPLC purity and low endotoxin levels. This research-grade peptide retains the cyclic disulfide structure and receptor binding properties of native vasopressin while incorporating a biotin tag for detection and isolation applications. It is designed for studying vasopressin receptor (V1a/V2) loca…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Biotin-(Arg8)-Vasopressin
CAS NO.	126703-17-1
Appearance	White to off-white lyophilized powder
Molecular Formula	C56H79N17O14S2
Molecular Weight	1310.55g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, phosphate‑buffered saline (PBS), or dilute acetic acid (e.g., 0.1% v/v). It is recommended to first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution.
Endotoxin	< 1.0 EU/mg
Biological Activity	This analog is a biotinylated version of Arg⁸-vasopressin, a V1a and V2 receptor agonist. It retains binding affinity for vasopressin receptors and is primarily used as a detection probe for receptor studies. The biotin tag enables high-affinity binding to streptavidin/avidin conjugates for applications such as pull-down assays, immunohistochemistry, and ELISA. Bioactivity should be validated in competitive binding assays.
Storage Conditions	Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze‑thaw cycles. For extended stability, store at –80 °C.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The peptide functions as a V1a and V2 receptor agonist, binding to these G protein-coupled receptors to activate phospholipase C (V1a) or stimulate adenylate cyclase (V2), leading to increased intracellular calcium or cAMP levels, respectively. The biotin moiety, attached via a flexible linker, does not significantly alter receptor affinity but enables high-affinity interaction with streptavidin/avidin systems for detection and capture. This allows researchers to visualize receptor distribution, isolate receptor complexes, and study ligand-receptor interactions without the need for radioactive labeling, while the Arg⁸ substitution maintains the peptide's potent vasopressor and antidiuretic activity.

2.PRODUCT INDICATIONS

This biotinylated vasopressin analog is indicated for research applications requiring visualization or isolation of vasopressin receptors. It is used in streptavidin-based pull-down assays to isolate V1a/V2 receptor complexes, immunohistochemistry and immunofluorescence to map receptor distribution in tissues, flow cytometry for cell surface receptor detection, and ELISA or Western blot applications. The product also serves as a non-radioactive ligand in receptor binding studies and autoradiography, facilitating investigations into vasopressin's roles in water balance, blood pressure regulation, stress response, and social behaviors.

3.CLINICAL EFFICACY OF PRODUCT

Biotin-(Arg⁸)-Vasopressin has no clinical efficacy or safety profile, as it is strictly a research reagent for preclinical investigations. The conjugate has not undergone clinical trials, regulatory evaluation, or safety assessment for diagnostic or therapeutic use. While it contributes to the fundamental understanding of vasopressin receptor biology and may inform the development of future diagnostic or therapeutic approaches, its utility is confined to laboratory research. Any clinical translation would require the development of distinct agents with comprehensive preclinical and clinical testing.

4.DELIVERY & SHIPPING

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Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Main Method: International Air Freight

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