[Lys8,Asn9] Neurotensin LANT-6 (8-13)

<p>[Lys⁸,Asn⁹] Neurotensin LANT-6 (8-13) is a synthetic, modified hexapeptide analog derived from the potent active core of neurotensin (NT). This research-grade peptide incorporates specific amino acid substitutions (lysine at position 8 and asparagine at position 9) within the LANT-6 sequence. These modifications are designed to systematically alter its receptor binding profile, selectivity, and potentially its me…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Lys⁸,Asn⁹] Neurotensin LANT-6 (8-13)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C36H58N8O9
Molecular Weight	746.91/mol
Purity (RP-HPLC)	≥95%
Solubility	Soluble in water (up to 5 mg/mL), dilute acetic acid, DMSO
Endotoxin	≤1.0 EU/mg
Biological Activity	Natural chicken intestinal peptide; agonist of NTS1/NTS2 receptors.
Storage Conditions	Store desiccated at -20°C to -80°C; avoid repeated freeze-thaw, moisture, and light. Stable for 1–2 years under proper storage
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This analog functions as a ligand for neurotensin receptors (NTS1 and NTS2). The substitutions of Lys⁸ and Asn⁹ (replacing the native residues in the NT(8-13) sequence) are strategically located within the receptor-binding pharmacophore. These changes are intended to modulate its interaction with the receptor's binding pocket, potentially altering its binding affinity, selectivity between NTS1 and NTS2 subtypes, and its functional efficacy .

2.PRODUCT INDICATIONS

This product is indicated for advanced research in neuropharmacology and medicinal chemistry focused on the neurotensin system. Key applications include: investigating the structure-activity relationship (SAR) of neurotensin analogs, specifically the role of residues at positions 8 and 9; studying receptor subtype selectivity (NTS1 vs. NTS2); evaluating the effects of these substitutions on peptide stability and in vivo activity; and serving as a key compound in the rational design and screening of novel neurotensin receptor ligands with optimized properties.

3.CLINICAL EFFICACY OF PRODUCT

[Lys⁸,Asn⁹] LANT-6 (8-13) is a research probe for drug discovery, not a clinical therapeutic. Its "efficacy" is defined by its utility in mapping the chemical space around the neurotensin pharmacophore. Research using such site-directed analogs provides critical data on which amino acid residues are permissive for changes and how specific substitutions affect receptor interaction.

4.DELIVERY & SHIPPING

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Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight

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