Neurotensin (9-13) CAS NO.60482-96-4

<p>Neurotensin (9-13) (CAS NO. 60482-96-4) is a synthetic pentapeptide representing the minimal C-terminal active fragment of the neurotensin (NT) neuropeptide. This high-purity, ultra-short sequence (Tyr-Ile-Leu-OH) constitutes the essential pharmacophore required for receptor interaction. Despite its small size, it retains significant, albeit reduced, biological activity compared to full-length NT, making it a fun…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Neurotensin (9-13)
CAS NO.	60482-96-4
Appearance	White to off-white lyophilized powder
Molecular Formula	C32H52N8O7
Molecular Weight	660.82/mol
Purity (RP-HPLC)	≥95%
Solubility	Soluble in water (up to 10 mg/mL), dilute acetic acid, or DMSO
Endotoxin	≤1.0 EU/mg
Biological Activity	Soluble in water (up to 10 mg/mL), dilute acetic acid, or DMSO
Storage Conditions	Store desiccated at -20°C to -80°C; avoid repeated freeze-thaw cycles. Stable for 2–3 years under proper storage.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This pentapeptide acts as a ligand for neurotensin receptors (NTS1 and NTS2). While its binding affinity is lower than the full-length peptide or the (8-13) fragment, the Tyr-Ile-Leu sequence is the core motif critical for receptor recognition and activation. It binds to the receptor's binding pocket, triggering downstream G protein-coupled signaling, primarily through the Gq pathway.

2.PRODUCT INDICATIONS

This product is indicated for specialized research in neuropharmacology and peptide chemistry, focusing on the molecular basis of ligand-receptor interactions. Key applications include: defining the minimal structural requirements for neurotensin receptor activation in structure-activity relationship (SAR) studies, serving as a scaffold or starting point for the design of novel NT receptor agonists or antagonists, investigating the contribution of the C-terminal tripeptide to overall binding energy and signaling, and as a reference compound in competitive binding assays to map receptor binding sites.

3.CLINICAL EFFICACY OF PRODUCT

Neurotensin (9-13) is a research-grade molecular probe, not a therapeutic. Its "efficacy" is defined by its critical role in fundamental science. By identifying the Tyr-Ile-Leu motif as the core pharmacophore, this fragment has been instrumental in mapping the active site of neurotensin receptors.

4.DELIVERY & SHIPPING

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Main Method: International Air Freight

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