Urocortin (rat) (free acid) CAS NO.171543-83-2

<p>Urocortin (rat) (free acid) (CAS 171543-83-2) is a premium rat-specific peptide with a defined molecular formula (C₂₀₆H₃₃₇N₆₁O₆₅) and molecular weight (4708.35 g/mol). As a professional Urocortin supplier, we deliver this product with ≥98% purity (RP-HPLC), low endotoxin levels, and intact disulfide bonds, with a free acid form optimizing CRF₁R/CRF₂R binding. Tailored for rat-focused stress physiology, neuroscien…

SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Urocortin (rat) (free acid)
CAS NO.	171543-83-2
Appearance	White to off-white lyophilized powder
Molecular Formula	C₂₀₆H₃₃₇N₆₁O₆₅
Molecular Weight	4708.35g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water (≥1 mg/mL, pH 3.0–5.0 for optimal dissolution), PBS buffer (pH 7.2–7.4, ≥1.5 mg/mL), and DMSO (≥2 mg/mL)
Endotoxin	< 1.0 EU/mg
Biological Activity	Potent agonist of corticotropin-releasing factor receptors (CRF₁R and CRF₂R); exhibits high affinity for both receptor subtypes in rat models; regulates stress response, anxiety-like behaviors, appetite, energy metabolism, and cardiovascular function; modulates neuronal excitability, inflammatory responses, and hypothalamic-pituitary-adrenal (HPA) axis activity
Storage Conditions	-20°C for long-term storage (stable for 2 years as lyophilized powder)
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Urocortin (rat) (free acid) exerts its biological effects through high-affinity binding to both CRF₁R and CRF₂R—G-protein-coupled receptors (GPCRs) widely expressed in the rat central nervous system (hypothalamus, amygdala), cardiovascular tissues, and peripheral organs involved in HPA axis regulation. The peptide’s dual disulfide bonds and rat-specific sequence optimize conformational stability, while the free acid form enhances receptor binding affinity by eliminating salt adduct interference.

2.PRODUCT INDICATIONS

CRF receptor research: Investigation of CRF₁R/CRF₂R structure-function relationships in rat models, serving as a standard ligand for dual-receptor activation assays, agonist/antagonist screening, and selectivity validation.

Stress physiology research: Study of HPA axis activation, stress response, and anxiety-like behaviors in rats, supporting exploration of stress-related neurological disorders.

Cardiovascular research: Evaluation of the peptide’s role in regulating rat cardiovascular function (vasodilation, cardiac contractility) and stress-induced cardiovascular responses.

3.CLINICAL EFFICACY OF PRODUCT

Urocortin (rat) (free acid) (CAS 171543-83-2) is widely utilized in rat-focused preclinical research, with proven efficacy in both in vitro and in vivo models. In rat neuronal cell assays, it exhibits potent dual CRF₁R/CRF₂R activation, effectively modulating stress-related signaling pathways with enhanced binding affinity due to its free acid form—ensuring precise and reproducible results.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.