Ac-[Leu28,31]-Neuropeptide Y (24-36) CAS NO.155709-24-3

<p>Ac-[Leu²⁸,³¹]-Neuropeptide Y (24-36) (CAS NO. 155709-24-3) is a synthetic, stabilized, and acetylated peptide fragment derived from the C-terminal region of neuropeptide Y (NPY). This research-grade analog incorporates two leucine substitutions (at positions 28 and 31) and an N-terminal acetylation, modifications designed to enhance its receptor binding affinity, selectivity, and metabolic stability. </p>

SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com

View on supplier website More from this supplier

Source categories

Peptides

About this product

Product information from the supplier.

TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Ac-[Leu28,31]-Neuropeptide Y (24-36)
CAS NO.	155709-24-3
Appearance	White to off-white lyophilized powder
Molecular Formula	C81H131N27O19
Molecular Weight	1787.1/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water, dilute acetic acid, or DMSO; gentle sonication may aid full dissolution
Endotoxin	≤1.0 EU/mg
Biological Activity	Selective agonist for neuropeptide Y (NPY) Y₅ receptors
Storage Conditions	Lyophilized powder: Store at -20°C to -80°C for long-term stability.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This engineered peptide acts as a potent and selective agonist for the neuropeptide Y Y2 receptor (NPY Y2R). The leucine substitutions at positions 28 and 31 are strategically placed within the receptor-binding domain to optimize interaction with the Y2 receptor pocket, enhancing selectivity over other NPY receptor subtypes. The N-terminal acetylation further increases its stability against enzymatic degradation.

2.PRODUCT INDICATIONS

This product is indicated for high-precision research in neuropharmacology and receptor biology. Key applications include: as a selective Y2 receptor agonist in studies of presynaptic inhibition, anxiety, and memory; for investigating the structure-activity relationship (SAR) of NPY analogs at the Y2 receptor; as a stable tool compound in long-duration functional assays; and in the development and screening of novel Y2 receptor-targeted therapeutics for conditions like obesity, anxiety, and epilepsy.

3.CLINICAL EFFICACY OF PRODUCT

Ac-[Leu²⁸,³¹]-NPY (24-36) is a sophisticated research probe, not a clinical therapeutic. Its "efficacy" lies in its optimized design as a selective and stable Y2 receptor ligand. Research using such engineered fragments provides critical insights into the pharmacophore required for Y2 receptor activation.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.