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Chemicals
Neuropeptide K, porcine CAS NO.106441-70-7
<p>Neuropeptide K, porcine (CAS 106441-70-7) is a high-purity (up to ≥98% RP-HPLC) tachykinin family peptide with molecular formula C₁₇₅H₂₈₄N₅₂O₅₂S and molecular weight 5980.6 g/mol. As a multi-functional neuropeptide, it acts as a potent vasodilator and anorexigenic agent, ideal for cardiovascular, neuroscience, and metabolic research. We are a trusted porcine NPK peptide supplier, offering custom TFA-free peptide …
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Neuropeptide K, porcine |
| CAS NO. | 106441-70-7 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₁₇₅H₂₈₄N₅₂O₅₂S |
| Molecular Weight | 5980.6g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in distilled water (up to 2 mg/mL); soluble in DMSO, dilute acid; slightly soluble in ethanol |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Member of the tachykinin family; acts as a potent vasodilator, secretagogue, and cardio-modulatory peptide; exhibits anorexigenic activity (decreases food intake in vivo); excites neurons and provokes behavioral responses; can be cleaved to release Neurokinin A; binds to tachykinin receptors |
| Storage Conditions | -20℃ for short-term storage |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Neuropeptide K, porcine is a 36-amino acid, C-terminally amidated member of the tachykinin peptide family, exerting diverse physiological effects via binding to tachykinin receptors (NK1 and NK2). As a multi-functional neuropeptide, it activates G-protein coupled receptor (GPCR)-mediated intracellular signaling pathways upon receptor ligation: binding to NK1/NK2 receptors triggers hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2), generating inositol trisphosphate (IP3) and diacylglycerol (DAG), which elevate intracellular calcium levels to mediate downstream responses.
2.PRODUCT INDICATIONS
Investigation of tachykinin receptor (NK1/NK2) signaling pathways and their roles in vasodilation, neurotransmission, and hormone secretion
Screening and validation of tachykinin receptor agonists/antagonists via in vitro assays (receptor binding, calcium mobilization, and smooth muscle relaxation assays)
Study of species-specific tachykinin family biology using porcine models to elucidate Neuropeptide K-mediated physiological processes3.CLINICAL EFFICACY OF PRODUCT
In vascular smooth muscle assays, it serves as a reliable positive control to evaluate the efficacy of tachykinin-targeted drugs for cardiovascular disorders (e.g., hypertension, vasospasm)
In porcine and rodent models of metabolic disorders, it aids in elucidating the role of Neuropeptide K in appetite suppression, supporting the development of novel therapeutics for obesity and eating disorders
It facilitates the characterization of tachykinin signaling in neuronal excitation and neurotransmitter release, providing insights for developing treatments for neurological disorders linked to dysregulated tachykinin pathways4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
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Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Main Method: International Air Freight
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