Prepro-Neuromedin S (70-103) (human) CAS NO. 894454-10-5

<p>Prepro-Neuromedin S (70-103) (human) is a defined 34-amino acid fragment derived from the human prepro-Neuromedin S precursor, encompassing the mature Neuromedin S core region along with flanking propeptide sequences. This research-grade peptide is synthesized as a lyophilized powder with ≥95% HPLC purity and low endotoxin levels, designed to study the processing, maturation, and precursor biology of the Neuromed…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Prepro-Neuromedin S (70-103) (human)
CAS NO.	894454-10-5
Appearance	White to off-white lyophilized powder
Molecular Formula	C180H271N49O44S
Molecular Weight	3857.5g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, phosphate‑buffered saline (PBS), or dilute acetic acid (e.g., 0.1% v/v). For best results, first dissolve in a small volume of 0.1% acetic acid or sterile water to prepare a 0.1–0.5 mg/mL stock solution.
Endotoxin	< 1.0 EU/mg
Biological Activity	This peptide corresponds to a fragment of the human prepro-Neuromedin S precursor (residues 70-103). It may contain the mature, bioactive Neuromedin S sequence and can be used to study peptide processing, precursor biology, or receptor interactions. Activity should be validated in relevant NMUR2 binding or functional assays (e.g., calcium flux).
Storage Conditions	Lyophilized powder: Store desiccated at –20°C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20°C; avoid repeated freeze‑thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

As a precursor fragment, Prepro-Neuromedin S (70-103) does not directly activate NMU receptors but serves as a substrate for proteolytic processing enzymes such as prohormone convertases. Cleavage at specific sites within this region generates the mature, bioactive Neuromedin S peptide, which then binds to NMUR2 with high affinity to initiate Gq/11-mediated signaling. The fragment itself may interact with processing enzymes and chaperones involved in peptide maturation, influencing the efficiency and regulation of Neuromedin S production. Its utility lies in modeling the biosynthetic pathway rather than direct receptor activation, providing a platform to study post-translational processing dynamics.

2.PRODUCT INDICATIONS

This peptide is indicated exclusively for research applications focused on the biosynthesis and processing of human Neuromedin S. It is employed to study prohormone convertase specificity, precursor cleavage kinetics, epitope mapping for antibody development, and the regulation of Neuromedin S maturation in cell-based systems and in vitroassays. The product serves as a reference substrate for validating processing enzymes, characterizing precursor fragments, and investigating disorders associated with impaired neuropeptide processing. It is not intended for diagnostic, therapeutic, or clinical use in humans.

3.CLINICAL EFFICACY OF PRODUCT

As a research reagent, Prepro-Neuromedin S (70-103) (human) has no established clinical efficacy or safety profile for therapeutic applications. The peptide has not undergone clinical trials, regulatory approval, or safety evaluation for any medical indication. While it contributes to fundamental understanding of Neuromedin S biosynthesis and may inform therapeutic strategies targeting peptide processing pathways in metabolic or circadian disorders, its utility remains confined to laboratory research. Any clinical translation would require development of entirely distinct therapeutic agents with comprehensive preclinical and clinical testing.

4.DELIVERY & SHIPPING

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