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Chemicals
Biotin-Neuromedin S (rat)
<p>Biotin-Neuromedin S (rat) is a synthetic, biotin-conjugated peptide corresponding to the rat isoform of Neuromedin S (NMS). This high-purity research reagent combines the full biological activity of endogenous rat NMS with a biotin tag, enabling its specific immobilization, capture, and highly sensitive detection in streptavidin-based assay systems. It is a crucial tool for elucidating the neuromedin S signaling …
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Biotin-Neuromedin S (rat) |
| CAS NO. | / |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C67H87N15O14 |
| Molecular Weight | 1326.53/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in water (≥1 mg/mL), 0.1% TFA in aqueous solution, dilute acetic acid & DMSO |
| Endotoxin | ≤1.0 EU/mg |
| Biological Activity | Potent agonist for rat neuromedin U receptors (NMU1/NMU2) with retained native bioactivity, EC₅₀ ≈ 0.3–2.0 nM in calcium mobilization functional assays. |
| Storage Conditions | Store at ≤ -20°C in a dry, dark, sealed container. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
This conjugate acts as a potent and selective endogenous agonist for the neuromedin U receptor 2 (NMUR2), which is highly expressed in the suprachiasmatic nucleus (SCN) of the brain. The biotin moiety, attached via a spacer, does not impede the peptide's receptor-binding domain. Upon engaging NMUR2, it activates Gq protein-coupled signaling, stimulating phospholipase C (PLC). This leads to the production of inositol trisphosphate (IP₃) and diacylglycerol (DAG), culminating in intracellular calcium mobilization.
2.PRODUCT INDICATIONS
This product is indicated for advanced molecular and in vitro research using rodent systems. Key applications include: performing surface plasmon resonance (SPR) or biolayer interferometry (BLI) to quantify binding kinetics and affinity for the rat NMUR2 receptor, conducting pull-down or co-immunoprecipitation assays to isolate receptor complexes, developing sensitive capture-based immunoassays (e.g., ELISA) for NMS detection, and receptor localization studies in tissue sections or cultured cells using streptavidin-based detection methods.
3.CLINICAL EFFICACY OF PRODUCT
Biotin-Neuromedin S (rat) is a specialized research tool and not a direct therapeutic. Its efficacy lies in its role as an enabling reagent for high-precision biomedical research. By allowing detailed molecular interaction studies in rodent models, it facilitates a deeper understanding of the NMS/NMUR2 pathway's role in regulating circadian rhythms and energy balance.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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Global Technology Co., Ltd.
