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Chemicals
Biotin-Neuromedin S (human)
<p>Biotin-Neuromedin S (human) is a synthetic, biotin-conjugated form of the human neuromedin S (NMS) peptide. This high-purity, dual-functional research reagent retains the full biological activity of native NMS while being covalently linked to a biotin molecule. This modification enables its specific capture, immobilization, and sensitive detection using streptavidin-based systems, making it an invaluable tool for…
SupplierGlobal Technology Co., Ltd.www.hqtechtirz.com
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Biotin-Neuromedin S (human) |
| CAS NO. | / |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C67H87N15O14 |
| Molecular Weight | 1326.53/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in water (≥1 mg/mL), 0.1% TFA in aqueous solution, dilute acetic acid & DMSO |
| Endotoxin | ≤1.0 EU/mg |
| Biological Activity | Potent agonist for neuromedin U receptors (NMU1/NMU2) with retained native bioactivity, EC₅₀ ≈ 0.2–1.8 nM in calcium mobilization assays |
| Storage Conditions | Store at ≤ -20°C in a dry, dark, sealed container. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
This conjugate functions as a full agonist for the neuromedin U receptor 2 (NMUR2), which is predominantly expressed in the central nervous system. The biotin tag, attached via a flexible linker, does not interfere with the peptide's core receptor-binding domain. Upon binding to NMUR2, it activates the associated Gq protein, triggering the phospholipase C (PLC) pathway.
2.PRODUCT INDICATIONS
This product is indicated for sophisticated research in neurobiology, circadian biology, and assay development. Key applications include: immobilization on streptavidin-coated surfaces for surface plasmon resonance (SPR) or biolayer interferometry (BLI) to study NMS-NMUR2 binding kinetics, pull-down assays to isolate and identify the NMUR2 receptor complex or interacting proteins, development of sensitive detection assays (e.g., ELISA) for NMS, and receptor localization studies using streptavidin-biotin visualization techniques.
3.CLINICAL EFFICACY OF PRODUCT
Biotin-Neuromedin S (human) is a research probe, not a therapeutic agent. Its efficacy is defined by its utility in enabling high-precision analytical techniques. By facilitating detailed biophysical and biochemical studies of the NMS-NMUR2 interaction, this reagent contributes to the fundamental understanding of this signaling pathway's role in regulating circadian rhythms, energy homeostasis, and stress.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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Global Technology Co., Ltd.
