Neuromedin U, rat CAS NO.117505-80-3

<p>Neuromedin U, rat is a 25-amino acid neuropeptide that serves as a potent endogenous ligand for neuromedin U receptors (NMUR1 and NMUR2). This research-grade peptide is synthesized to high purity (≥95% HPLC) and supplied as a lyophilized powder with low endotoxin levels, ensuring reliability for in vitro and in vivo studies. It is widely used to investigate the physiological roles of NMU signaling in energy homeo…

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Neuromedin U, rat
CAS NO.	117505-80-3
Appearance	White to off-white lyophilized powder
Molecular Formula	C124H180N34O31
Molecular Weight	2643.03 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, phosphate‑buffered saline (PBS), or dilute acetic acid (e.g., 0.1 % v/v). It is recommended to first dissolve in a small volume of 0.1 % acetic acid or sterile water to prepare a 0.1–1.0 mg/mL stock solution.
Endotoxin	< 1.0 EU/mg
Biological Activity	Neuromedin U is an endogenous neuropeptide that acts as a potent agonist at the neuromedin U receptors (NMUR1 and NMUR2). It regulates diverse physiological functions including smooth muscle contraction, energy homeostasis, appetite suppression, stress response, and circadian rhythms. Activity can be confirmed in NMUR-expressing cell-based assays (e.g., calcium flux or cAMP inhibition) or in bioassays measuring ileal or uterine smooth muscle contraction.
Storage Conditions	Lyophilized powder: Store desiccated at –20 °C or below, protected from light, for long‑term stability. Reconstituted solution: Aliquot and store at ≤ –20 °C; avoid repeated freeze‑thaw cycles. For extended stability, store at –80 °C
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The peptide exerts its biological effects by binding with high affinity to G protein-coupled receptors NMUR1 and NMUR2, primarily coupling to Gq/11 proteins. Activation of these receptors stimulates phospholipase C, leading to inositol trisphosphate (IP3) production and intracellular calcium mobilization. This signaling cascade modulates various downstream pathways, including smooth muscle contraction, inhibition of cAMP accumulation, and regulation of neurotransmitter release. The rat isoform exhibits species-specific potency and is particularly valuable for studying NMU receptor pharmacology in rodent models.

2.PRODUCT INDICATIONS

Neuromedin U, rat is indicated exclusively for research applications in preclinical studies of neuropeptide signaling and physiology. It is employed to investigate the roles of NMU in appetite regulation, energy expenditure, gastrointestinal motility, uterine contraction, and stress-induced behaviors. The product serves as a reference agonist for validating NMUR1/NMUR2 expression, screening receptor antagonists, and characterizing NMU signaling pathways in cell-based assays and animal models. It is not intended for diagnostic, therapeutic, or clinical use in humans.

3.CLINICAL EFFICACY OF PRODUCT

As a research reagent, Neuromedin U, rat has no established clinical efficacy or safety profile for therapeutic applications in humans. The peptide has not undergone clinical trials, regulatory approval, or safety evaluation for any medical indication. While it contributes to fundamental understanding of NMU biology and potential therapeutic targets for obesity, gastrointestinal disorders, and metabolic diseases, its utility remains confined to laboratory research. Any translation to clinical applications would require development of human-specific analogs with comprehensive preclinical and clinical testing.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.