[Pro7]-Neurokinin B CAS NO.120814-48-4

<p>[Pro⁷]-Neurokinin B (CAS NO. 120814-48-4) is a synthetic, modified analog of the endogenous neuropeptide Neurokinin B (NKB). This research-grade peptide features a specific proline substitution at position 7, a modification designed to alter its conformational structure and receptor interaction profile.</p>

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Pro⁷]-Neurokinin B
CAS NO.	120814-48-4
Appearance	White to off-white lyophilized powder
Molecular Formula	C55H77N13O14S2
Molecular Weight	1208.43/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (≥1 mg/mL), 0.1% TFA in aqueous solution, dilute acetic acid and DMSO
Endotoxin	≤1.0 EU/mg
Biological Activity	Potent and selective agonist for neurokinin-3 (NK3) receptors; enhanced metabolic stability and receptor binding affinity vs native Neurokinin B, EC₅₀ ≈ 0.2–1.0 nM in calcium mobilization functional assays.
Storage Conditions	Store at ≤ -20°C in a dry, dark, sealed container.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This analog functions as a ligand for tachykinin receptors, with its activity profile shaped by the proline substitution. Proline introduces a structural kink into the peptide backbone, which can significantly affect its binding affinity and selectivity for the neurokinin 3 (NK3) receptor compared to the native Neurokinin B sequence.

2.PRODUCT INDICATIONS

This product is indicated for specialized research in neuropharmacology, endocrinology, and peptide chemistry. Key applications include: studying the impact of specific amino acid substitutions (particularly proline) on tachykinin peptide conformation and receptor selectivity, investigating the physiological roles of NK3 receptor signaling in areas such as gonadotropin-releasing hormone (GnRH) secretion and blood pressure regulation, and serving as a comparative tool in structure-activity relationship (SAR) studies to develop selective NK3 receptor agonists or antagonists.

3.CLINICAL EFFICACY OF PRODUCT

[Pro⁷]-Neurokinin B is a research probe and not a clinical therapeutic. Its efficacy lies in its utility as a molecular tool for dissecting peptide-receptor interactions. Studies using such site-specifically modified analogs are fundamental for mapping the pharmacophore of Neurokinin B and understanding how structural changes influence function.

4.DELIVERY & SHIPPING

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