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Chemicals
Prepro-Atrial Natriuretic Factor (104-123) (human) CAS NO.112160-83-5
<p><div class="ybc-p">Prepro-Atrial Natriuretic Factor (104-123) (human) (CAS NO. 112160-83-5) is a synthetic, 20-amino acid peptide fragment corresponding to residues 104-123 of the human prepro-ANP precursor protein. This high-purity peptide represents a segment of the prohormone's mid-region and is a specialized research tool for studying atrial natriuretic peptide (ANP) biosynthesis, processing, and potentia…
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TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Prepro-Atrial Natriuretic Factor (104-123) (human) |
| CAS NO. | 112160-83-5 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C94H171N31O28 |
| Molecular Weight | 2183.6/mol |
| Purity (RP-HPLC) | ≥98% |
| Solubility | Soluble in water (≥1 mg/mL), 0.1% TFA in water, or dilute acetic acid |
| Endotoxin | ≤1.0 EU/mg |
| Biological Activity | This peptide segment is a prohormone region of ANF and does not exhibit direct vasoactive activity. |
| Storage Conditions | Store at ≤ -20°C in a dry, dark environment. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
This peptide is derived from the prepro-ANP sequence that lies outside the region encoding the mature, circulating ANP (99-126). Its precise biological activity, if any, is not related to classical NPR-A activation. Its primary research utility lies in its role as a defined antigenic sequence. It may be involved in intracellular processing or act as a precursor for other, less-characterized peptide fragments.
2.PRODUCT INDICATIONS
This product is indicated for specialized research in cardiovascular endocrinology, peptide biochemistry, and assay development. Key applications include: generating specific antibodies for measuring ANP precursor fragments (e.g., pro-ANP, NT-proANP) in immunoassays, studying the proteolytic processing and cellular trafficking of prepro-ANP, investigating potential biological activities of non-mature ANP regions, and serving as a reference standard in mass spectrometry or chromatographic studies of ANP-related peptides.
3.CLINICAL EFFICACY OF PRODUCT
Prepro-ANF (104-123) is a research reagent with no direct therapeutic application. Its clinical "efficacy" is indirect but significant. Antibodies raised against this and similar pro-region peptides are fundamental to clinical diagnostic assays that measure N-terminal pro-atrial natriuretic peptide (NT-proANP).
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